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Microcystic Adnexal Carcinoma Versus Desmoplastic Trichoepithelioma: Desmoplastic trichoepithelioma (DTE) has cords of banal cells and small, superficial keratin cysts just like MAC, but duct/lumina formation is lacking.
Microcystic Adnexal Carcinoma Versus Syringoma: Unlike DTE and MAC, syringoma has many duct lumina that are easily identified; they do not typically have thin cords of cells in the absence of duct lumina.
Sellheyer, "Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma," Journal of Cutaneous Pathology, vol.
Patel, "The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers," Journal of Cutaneous Pathology, vol.
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. Am J Dermatopathol.
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Vulvar syringomas with deep extension: a potential histopathologic mimic of microcystic adnexal carcinoma. Int J Gynecol Pathol.
Microcystic adnexal carcinoma: an immunohistochemical study including markers of proliferation and apoptosis.
Cutaneous adnexal carcinomas are extremely rare, reported to represent 0.005% of all skin tumors.
Lassau et al., "Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma," Journal of the European Academy of Dermatology and Venereology, vol.
Hoang, "The diagnostic utility of immunohistochemistry in distinguishing primary skin adnexal carcinomas from metastatic adenocarcinoma to skin: an immunohistochemical reappraisal using cytokeratin 15, nestin, p63, D2-40, and calretinin," Modern Pathology, vol.
Ivan et al (25) extended the analysis of p63 to include metastases from adnexal carcinomas and found that 91% of PCANs were strongly marked with p63 and, excluding apocrine and mucinous carcinoma, their metastases labeled similarly.
A number of carcinomas may display predominant clear cells in the skin, including squamous cell carcinoma (Figure 3, A) and adnexal carcinomas, such as tricholemmal carcinoma, sebaceous carcinoma, and hidradenocarcinoma.
When making a diagnosis of hidradenocarcinoma, the differential diagnosis includes several other tumors, such as lipomas, hemangiomas, lymphangiomas, squamous cell carcinomas, basal cell carcinomas, malignant melanoma, other malignant adnexal carcinomas, and metastatic tumors to the skin.
(65) In addition, most primary adnexal carcinomas and their metastases express p63, whereas visceral adenocarcinomas and their cutaneous metastases do not make this stain a useful adjunct to distinguish primary cutaneous adnexal carcinomas from metastatic visceral adenocarcinomas.