Effron et al., "Clusterrandomized clinical trial examining the impact of platelet function testing on practice: The Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal assessment of treatment patterns and events after acute coronary syndrome prospective open label antiplatelet therapy study," Circulation: Cardiovascular Interventions, vol.
Antiplatelet tests showed decreases in aggregation in response to arachidonic acid (P = 0.034) and adenosine diphosphate (P<0.0001) for patients treated with aspirin and clopidogrel, respectively.
Pomolic acid (PA), triterpenoid isolated from Licania pittieri, has previously shown a potent ability to inhibit adenosine diphosphate (ADP)-and epinephrine-induced human platelet aggregation.
Platelet aggregation induced by low concentrations of adenosine diphosphate (ADP) and epinephrine, and serum thromboxane B2 decreased by 45% both in humans and animals after GLA supplementation.
(1) The enzyme catalyses the conversion of phosphoenolpyruvate (PEP) to pyruvate, producing adenosine triphosphate (ATP) from adenosine diphosphate (ADP) in the process.