adenosine deaminase


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Related to adenosine deaminase: Adenosine deaminase deficiency
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Synonyms for adenosine deaminase

an enzyme found in mammals that can catalyze the deamination of adenosine into inosine and ammonia

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References in periodicals archive ?
There are no international standardisation programs for adenosine deaminase assays and published cut-off should therefore be viewed with caution.
Both of these sets of mutant mice were treated with the enzyme adenosine deaminase enzymes to lower adenosine levels.
SCID due to a deficiency of adenosine deaminase is fatal if left untreated.
Here we describe the generation of induced pluripotent stem (iPS) cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance; these diseases include adenosine deaminase deficiency-related severe combined immunodeficiency (ADA-SCID), Shwachman-Bodian-Diamond syndrome (SBDS), Gaucher disease (GD) type III, Duchenne (DMD) and Becker muscular dystrophy (BMD), Parkinson disease (PD), Huntington disease (HD), juvenile-onset, type 1 diabetes mellitus (JDM), Down syndrome (DS)/trisomy 21, and the carrier state of Lesch-Nyhan syndrome.
They address the move toward a universal platform for autologous stem cell gene therapy and also address adenosine deaminase deficiency, insertion of a transgene into Chromosome 19, site-specific integrating vectors, gene targeting, engineering of homing endonucleases and novel sequence-specific DNA binding and modifying, gene targeting mediated by hyper-dependent adenoviral vectors, and multipotent progenitor cells.
Interestingly, the plasma concentrations of adenosine in children with adenosine deaminase deficiency-severe combined immunodeficiency (ADA-SCID) are similar (6 [micro]mol/l) (6).
Pleural fluid analysis was consistent with exudate, and adenosine deaminase level of fluid was normal.
Anderson, a member of the team that attempted the first gene therapy in 1990, recalled that the first clinical trial, conducted in a child with adenosine deaminase (ADA) deficiency was sufficiently successful that "we all got a little too optimistic about how simple it would be to alter a human body in a sufficient magnitude to actually treat a disease.
The Hokkaido University Hospital will conduct research into adenosine deaminase deficiency, while Tohoku University Hospital will engage in studies of X-Linked Severe Combined Immunodeficiency, the officials said.
The genesis of cladribine can be traced to 1977, when Carson was a junior researcher at Scripps working on a rare genetic disorder called adenosine deaminase (ADA) deficiency.
In the young girl's case, the disorder stems from a flawed gene that is the genetic blueprint for making a substance, adenosine deaminase (ADA), that plays a crucial role in immune defenses.
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