activity in pleural effusions: An aid to differential diagnosis.
Serum and erythrocyte adenosine deaminase
activities in patients with Behcet's disease.
Role of adenosine deaminase
in the early stages of precursor T cell maturation.
There are no international standardisation programs for adenosine deaminase
assays and published cut-off should therefore be viewed with caution.
Both of these sets of mutant mice were treated with the enzyme adenosine deaminase
enzymes to lower adenosine levels.
SCID due to a deficiency of adenosine deaminase
is fatal if left untreated.
Here we describe the generation of induced pluripotent stem (iPS) cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance; these diseases include adenosine deaminase
deficiency-related severe combined immunodeficiency (ADA-SCID), Shwachman-Bodian-Diamond syndrome (SBDS), Gaucher disease (GD) type III, Duchenne (DMD) and Becker muscular dystrophy (BMD), Parkinson disease (PD), Huntington disease (HD), juvenile-onset, type 1 diabetes mellitus (JDM), Down syndrome (DS)/trisomy 21, and the carrier state of Lesch-Nyhan syndrome.
They address the move toward a universal platform for autologous stem cell gene therapy and also address adenosine deaminase
deficiency, insertion of a transgene into Chromosome 19, site-specific integrating vectors, gene targeting, engineering of homing endonucleases and novel sequence-specific DNA binding and modifying, gene targeting mediated by hyper-dependent adenoviral vectors, and multipotent progenitor cells.
Interestingly, the plasma concentrations of adenosine in children with adenosine deaminase
deficiency-severe combined immunodeficiency (ADA-SCID) are similar (6 [micro]mol/l) (6).
Pleural fluid analysis was consistent with exudate, and adenosine deaminase
level of fluid was normal.
Effect of guanosine nucleotides and adenosine deaminase
on CGS 21680 activation effect
Anderson, a member of the team that attempted the first gene therapy in 1990, recalled that the first clinical trial, conducted in a child with adenosine deaminase
(ADA) deficiency was sufficiently successful that "we all got a little too optimistic about how simple it would be to alter a human body in a sufficient magnitude to actually treat a disease.
The Hokkaido University Hospital will conduct research into adenosine deaminase
deficiency, while Tohoku University Hospital will engage in studies of X-Linked Severe Combined Immunodeficiency, the officials said.
The genesis of cladribine can be traced to 1977, when Carson was a junior researcher at Scripps working on a rare genetic disorder called adenosine deaminase
In the young girl's case, the disorder stems from a flawed gene that is the genetic blueprint for making a substance, adenosine deaminase
(ADA), that plays a crucial role in immune defenses.