The first group is epithelial polyps, such as fundic gland polyps (FGP), hyperplastic polyps (HP),
adenomatous polyps (AP), hamartomatous polyps and non-hamartomatous-polyposis syndromes.
The degree of dysplasia in
adenomatous polyp is assessed by looking into the features like increase in number of glands and cells per unit area compared to normal mucosa, nuclear hyperchromasia, elongation and stratification.
Conclusion: The commonest colon polyp type was
adenomatous polyp. Screening programmes, such as stool occult blood testing and colonoscopies, are recommended.
The preferred test or tests are those that will prevent CRC, rather than just detect the
adenomatous polyp. At present only optical colonoscopy offers this possibility, as the polyp can be removed during the examination.
Overall, about one percent of
adenomatous polyps less than one cm in size will undergo this change, 10 percent of
adenomatous polyps greater than one cm will become malignant within 10 years and 25 percent of adenomas greater than one cm will become malignant within 20 years.
Adenomatous polyp - A grape-like shaped growth that occurs on the lining of the colon and rectum.
(%) OR (95% CI) p Colonoscopy findings Overall CRN 13 (8.6%) 1.42 (0.86-1.83) 0.03 Advanced CRN 8 (5.2%) 1.12 (0.26-1.37) 0.06 Villous
adenomatous polyp 1 (0.6%) 1.06 (0.81-1.67) 0.10 Size of polyp <1 cm 2 (1.3%) 1.27 (0.38-2.78) 0.45 High-grade dysplasia or invasive adenocarcinoma 4 (2.6%) 2.04 (1.18-4.87) 0.02 No.
Report of a case of adenocarcinoma arising within a mixed hyperplastic
adenomatous polyp," The American Journal of Surgical Pathology, vol.
[12] found tubular adenoma was the most common benign tumour (83%) of all the benign tumours, whereas in our study it was
adenomatous polyp (9%).
The vast majority of polyps are benign, hyperplastic polyps, and <5% of the asymptomatic screening population has a significant
adenomatous polyp. (5) Hence, if OC is the primary screening method, then >95% of the asymptomatic population would under go OC unnecessarily with its inherent risks of bowel perforation and anesthesia.
The evidence for adenoma prevention was quite strong when the two celecoxib trials were prematurely halted following the September 2004 suspension of the
Adenomatous Polyp Prevention on Vioxx (APPROVE) trial in response to cardiovascular concerns with that COX-2 inhibitor.
A test with high specificity is negative in the absence of an
adenomatous polyp or cancer, and a test with high sensitivity is positive when an
adenomatous polyp or cancer is present (Ahlquist, 2002).
For example, it takes an average of estimated 15 to 20 years for a small
adenomatous polyp to become malignant.
But in some people, the doctor first finds a kind of benign tumor called an
adenomatous polyp.
This type of serrated
adenomatous polyp shows complex, occasional filiform growth with ectopic crypt formation and exhibits characteristic cytologic features.