changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation.
The products of these neurons regulate release of adenohypophysial
hormones other than those regulating reproduction.
It has been reported by Cano et al (199) that Cd modifies expression of two major clock genes, period (Per) 1 and Per 2, in the hypothalamic-pituitary unit while melatonin administration counteracted most of the effects of Cd and augmented hypothalamic Per 2, and adenohypophysial
Per 1 and Per 2 gene expression.
In the majority of cases, there is a genetic (gene mutations) or structural (mass effect or infiltration) basis for central hypothyroidism, and there is simultaneous deficiency of other adenohypophysial
2) The major exception to this rule is the reticulin stain, which is essential to distinguish normal adenohypophysial
architecture, hyperplasia, and adenoma.