These tumors are defined as containing both adenocarcinomatous
and squamous carcinoma components (at least 10%) of each.
In our patient, adjuvant chemotherapy was not administered because only CIS was found in the radical cystectomy specimen, even though high-grade UC and adenocarcinomatous
differentiation were present in the TURBT specimen.
The neoplasm has an adenocarcinomatous
pattern, producing ductules and acini, and sometimes papillary formations.
On analysis, it was shown the use of homeopathically prepared Carcinosin and Phytolacca were associated with a reduction in the viability of the adenocarcinomatous
cells, an increase in the rate of cell death, a preferential loss of telomeric DNA and early apoptosis induction from and of these cells.
In approximately 50% of the patients, pathological findings reveal adenocarcinomatous
Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous
cells and tissues is mediated by the phosphatidylinositol 3-kinase.
The most impressive difference between squamous and adenocarcinomatous
samples was the very low expression of only one splice variant ([alpha]+[beta]-) in 2 of 15 (13.3%) adenocarcinomas, one of which was positive and the other negative for telomerase activity.
The list of other malignant neoplasms includes variants of squamous cell carcinoma (e.g., verrucous carcinoma), carcinomas of glandular origin (e.g., neuroendocrine, adenocarcinomatous
, adenoid cystic, and mucoepidermoid tumors), sarcomas of structural origin (e.g., fibrosarcoma, chondrosarcoma, osteosarcoma, rhabdomyosarcoma, leiomyosarcoma, and liposarcoma), and tumors of lymphocytic origin (e.g., lymphoma and plasmacytoma).
The pleural aspirate was bloody and the cytological examination positive for adenocarcinomatous
Because immunohistochemical result of neuroendocrine markers would be negative or only patch staining , especially in cases with more adenocarcinomatous
component , we suggested neuroendocrine marker should stain more than one slide of the tumor, and the focal patch staining pattern should be considered positive for the entity.
Interestingly, GNAS mutations have been found in invasive adenocarcinomatous
components associated with IPMNs but not in de novo, isolated ductal adenocarcinomas.