Higher blood sugar increased the participants' CEdG adducts
Termini and his colleagues looked for a specific type of damage in the form of chemically modified DNA bases, known as adducts
, in tissue culture and rodent models of diabetes.
The principle of action of Cisplatin in combating cancer involves exerting its cytotoxicity upon cancer cells through the formation of DNA adducts
that include mono-, inter, and intrastrand cisplatin DNA cross-links that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis.
The team now plans to replicate the study on a larger scale, to see how the level of DNA adducts
differs between e-cigarette users and regular cigarette users.
The epoxy adduct
or epoxy adduct-BnOH mixtures were stirred via a propeller mixer at 2,000 rpm for 1 min.
Few attempts have been performed to incorporate the D-A adduct
into the crosslinker instead of the epoxy monomer, which is a strategy that could allow to introduce the self-healing properties to a wide range of commercial epoxies [12, 13].
"If a BPDE adduct
occurs in a tumor suppressor gene and isn't repaired in a timely manner, it can lead to a permanent mutation that turns a cell cancerous," said Wentao Li, PhD, a postdoctoral researcher and lead author of the study.
--the study must compare the 1-OHP in urine, DNA adduct
levels and micronucleus frequency in peripheral blood lymphocytes of subjects with active GSTM1 and null GSTM1 carriers between occupationally exposed workers and the non-occupationally exposed population;
A repeat DNA adduct
investigation a year later proved negative.
The energy of interactions within the azole 7-alanine adduct
7AlaB, which was optimized at the B3LYP/6-31G(d,p) level of theory, was -9.36 when calculated at the B3LYP/631G(d,p) or -8.77 kcal [mol.sup.-1] when calculated at the B3LYP/6311++G(2d,3p) level of theory.
In cytoplasm, BPDE (C) forms tetrols (T), protein adduct
(A) and GSH conjugation
The metabolites can bind with proteins to form stable adducts
called MDA--acetaldehyde--protein adduct
Recently synthesis of Baylis-Hillman adduct
by using 4-hydroxy-2-naphthalic acids and benzaldehydesuccinimides , KCN in DMSO/H2O2, AC2O/amberlysyt-15 , N-sulfonylimines .
Selection was primarily based on correlations (r [greater than or equal to] 0.75, [less than or equal to] -0.75, p < 0.05) of gene expression with toxic dietary exposures (i.e., genotoxic or immunotoxic) estimated based on FFQs, CALUX assay-based evidence of exposure to estrogenic-, androgenic-, and dioxin-like compounds, Hb adduct
levels, and MN frequencies.
The complex of reactive metabolite and DNA structure is known as a DNA adduct
. In the case of BPDE it is a BPDE-DNA adduct