(a) 18 carbon LPA species with an acyl group
in sn-1 position and one saturation are the most potent activator of the [LPA.sup.1] and [LPA.sup.2] receptors .
Indeed, the increase of LCAT activity observed in this study was accompanied by a reduction in [HDL.sub.3] amounts, PL-[HDL.sub.3] (LCAT substrate), UC-[HDL.sub.3] (acyl group
acceptor) and an increase in HDL2 amounts and CE-[HDL.sub.2] (reaction product) indicating an important conversion of [HDL.sub.3] into [HDL.sub.2].
The highest activity (fixed as 100%) was towards p-NP butyrate (C4 acyl group
2B and Table 1) showed that attachment of an additional glucose moiety at C-6 of the terminal glucose in penicilloside A ([IC.sub.50] 7.07 [micro]g/ml) led to the loss of activity in penicilloside B ([IC.sub.50] > 12.5 [micro]g/ml), while the attachment of an additional acyl group
(isovaleeroyl moiety) in penicilloside C led to regain of the activity ([IC.sub.50] 8.44 [micro]g/ml), this may indicate that the lipophilicity increase the activity.
On the basis of structure activity relationship it is postulated position of hydroxyl group is responsible for radical scavenging activity and substitution of acyl group
in case of compound 1,2 and 3 may decrease the affinity of compound to scavenge the free radicals generated by DPPH.
This fragment results from the loss of elements of both [(C[H.sub.3]).sub.3]N and [C.sub.4][H.sub.8] and the side chain acyl group
as RCOOH (figure 4).
Acylcarnitines are indicated with an uppercase C followed by the number of carbons comprising the fatty acyl group
. Dicarboxylic acids are indicated with an uppercase DC, aliphatic hydroxy fatty acyl groups
with an OH, and unsaturated species with a colon followed by the number of unsaturated sites.
Peaks at m/z 74 and m/z 87 were obtained by cleavage at specific point by electron transfer and neutral loss at C-2 and C-3 from acyl group
thereby generating the stable fragments of base peak (m/z 74) and second abundant peak m/z 87, respectively [Fig.
Modulation of the positional specificity of lecithin-cholesterol acyltransferase by the acyl group
composition of its phosphatidylcholine substrate: role of the sn-1-acyl group.
The properties of these classes of compounds have been recently exploited with the aim to design and develop novel therapeutic agents that can display acyl group
transfer capabilities and serve for the evaluation of novel candidate drugs for the treatment of various diseases.
In the second step, the acyl group
is transferred to the acyl acceptor amine and the amine is linked to the glutamine residue via a peptide (isopeptide) bond.
Addition of acyl groups
to dicarboxylic acid can provide potential coordination atoms or super molecular identification points.
[USPRwire, Thu Oct 18 2018] Polyimide polymers are derived from monomers of imide group, a functional group comprising two acyl groups
. Imides are primarily employed in the manufacturing of high strength polymers for varied applications.