Tc-99mDMSA scan in the diagnosis of acute pyelonephritis
in children: relation to clinical and radiological findings.
Evaluation of the use of DMSA in culture positive UTI and culture negative acute pyelonephritis
. Indian Pediatrics 2005; 42: 691-696.
Most patients with acute pyelonephritis
do not require any diagnostic imaging procedures.
The IRIS 1 trial randomized 198 girls and 89 boys aged 1 month to 7 years (mean age, 15 months) presenting with their first documented episode of acute pyelonephritis
. They received either oral co-amoxiclav (50 mg/kg per day, in three divided doses, for 10 days), or parenterally administered ceftriaxone (50 mg/kg per day in a single dose for 3 days), followed by orally administered co-amoxiclav (50 mg/kg per day, in three divided doses, for 7 days).
Retrospective study of children with acute pyelonephritis
. Evaluation of bacterial etiology, antimicrobial susceptibility, drug management and imaging studies.
is presenting additional data at ID Week 2017 from its ZEUS Phase 2/3 clinical trial evaluating the investigational antibiotic Zolyd (fosfomycin for injection, also known as ZTI-01, in hospitalized patients with complicated urinary tract infections (cUTI), including acute pyelonephritis
, the company said.
Zavante recently reported that ZOLYD met the primary endpoint of statistical non-inferiority to piperacillin/tazobactam in the pivotal ZEUS Phase 2/3 clinical trial in hospitalized adults with complicated urinary tract infections (cUTI), including acute pyelonephritis
Further the age and sex wise distribution of the lesions with the percentage was done and overall the kidneys were affected in the age group of 4-6th decade (Table 2) The nonneoplastic lesions were further classified as various types of Chronic pyelonephritis associated with hydronephrosis due to renal stones, Acute pyelonephritis
and perinephric abscess, PUJ obstruction, Adult polycystic kidneys and Multicystic dysplastic kidney (Table 3) Majority of the nonneoplastic lesions were in the category of chronic pyelonephritis with hydronephrosis due to renal stones (32.5%).
[sup.21,22] Hoberman and colleagues, in a large prospective trial of oral versus intravenous therapy for UTIs in young children, found no significant difference in scarring among children who presented after 24 hours of fever compared with those who presented sooner.[sup.21] Hewitt and colleagues used data from 2 multicentre, prospective, randomized controlled trials to demonstrate a 30.7% scar rate on dimercaptosuccinic acid (DMSA) 12 months after an acute pyelonephritis
.[sup.22] Progressive delay in antibiotic treatment from <1 day to >5 days after onset of fever was not associated with increased scarring.
Mild to moderate vesicoureteral reflux did not increase the incidence of urinary tract infections, recurrent pyelonephritis, or renal scarring in children with acute pyelonephritis
, reported Dr.
SAN DIEGO--Renal scars and moderately reduced renal function are common in women with previous acute pyelonephritis
, but long-term serious clinical complications appear to be rare, Dr.
This study was undertaken to investigate the clinical utility of a widespread practice: the 24-hour in-hospital observation period that commonly follows when the treatment of patients hospitalized with acute pyelonephritis
is switched from intravenous to oral antibiotics.
Nabriva Therapeutics announced that the FDA has accepted the new drug application, or NDA, and granted a priority review for Contepo to treat complicated urinary tract infections, or cUTIs, including acute pyelonephritis
. The acceptance of the NDA indicates that the FDA has deemed the application sufficiently complete to allow a substantive review.
Zavante recently reported that Zolyd met the primary endpoint of statistical non-inferiority to piperacillin/tazobactam in the pivotal ZEUS Phase 2/3 clinical trial in hospitalized adults with complicated urinary tract infections, including acute pyelonephritis
. The company plans to submit a New Drug Application to the FDA in early 2018.
(3.) Dovlatian AA, Morozov DV, The surgical treatment of suppurative destructive forms of acute pyelonephritis
in pregnant women, Urol nefrol (mosk) 1996 Nov-Dec: 6: 19-23.