At a meeting of the FDA's Cardiovascular and Renal Drugs Advisory Committee, the expert panel agreed that nesiritide should be approved for treating acute congestive heart failure
(CHF), with adequate warnings about the possible risk of hypotension with the drug.
Within 1 week, the patient developed acute congestive heart failure
, which was probably related to the sodium content of the ticarcillin.
Acquisition Gives Merck Access to KW-3902, an Investigational Phase 3 Compound for Acute Congestive Heart Failure
While Urodilatin is still in clinical development, ANP and another member of the natriuretic peptide hormone family, BNP, are clinically available for the treatment of acute congestive heart failure
The study concluded that elevated NT-proBNP concentration in the presence of a low GFR strongly predicts 60-day mortality in patients with acute congestive heart failure
(CHF), better than either individual parameter alone; 60-day survival was similar in patients with either a low GFR or a high NT-proBNP.