"A policy of 'active surveillance
' has been developed as a way to combat this uncertainty, but it requires invasive follow-ups and constant reminders that a patient has a cancer with an uncertain natural history.
Data have shown that active surveillance
is safe, but the researchers note that those data have been drawn from clinical trials or studies in large academic institutions.
Number of infections diagnosed by culture or culture-independent diagnostic tests (CIDTs), by pathogen, year, and culture status--CDC's Foodborne Diseases Active Surveillance
Network, * 2015-2018 ([dagger])
The active surveillance
covers Matarinao Bay in Eastern Samar, Irong-irong Bay in Samar, Maqueda Bay in Samar, Villareal Bay in Samar; Carigara Bay in Leyte; Biliran waters in Biliran province, coastal waters of Daram, Samar, San Pedro Bay in Samar, and Cancabato Bay in Tacloban City.
Under the contract Dendreon will provide Decipher Biosciences with tumour samples from its Phase three ProVent trial (NCT03686683), which will assess the effectiveness of sipuleucel-T in decreasing disease progression in men with prostate cancer on active surveillance
. Decipher Biosciences will utilise its whole transcriptome Decipher assay to evaluate the biological behaviour of a patient's tumour and its GRID software and database to assess gene expression signatures that may be associated with sipuleucel-T response.
Because active surveillance
is not an option for intermediate-and high-risk prostate cancer, there are very few studies regarding these groups.
(wait and watch) is now being internationally trialled as an alternative approach to surgery.
Although active surveillance
is increasingly accepted as an initial management strategy for patients with low-risk (Gleason score 6 or less) localized prostate cancer, the majority of patients with low-risk disease still receive definitive treatment.
It is now used frequently in the context of active surveillance
, as well as in patients with persistent suspicion of prostate cancer despite a prior negative biopsy (1,5).
The Ombudsman's report stated: "Prostate cancer patients on active surveillance
should be properly and appropriately monitored.
A European consensus on the management of DF has recently been published, advocating active surveillance
as the initial treatment modality, with systemic treatment, surgery or radiotherapy in case of tumor progression .
has been proposed as a management strategy for low-risk, localized PCa, but there is an urgent need for further clinical studies to establish the criteria for recommending this approach.
The current direction of low-risk PCa management is towards active surveillance
(AS), which is a way to monitor localized PCa, rather than treating it right away.
The adverse effects and consequences related to treatment with curative-intent of potentially indolent PCa led to the introduction of Active Surveillance
(AS)  as an alternative intended to defer curative treatment until biological activity of the tumor becomes evident [4,5].