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Notably, acinar cells have been shown to metabolize alcohol (i.
The acinar cell adenomas we observed in the rats were characterized by being a discrete mass consisting of tubular and acinar structures composed of small acinar cells with brightly eosinophilic cytoplasm and lacking zymogen granules.
Acinar cell carcinoma is a rare malignant exocrine pancreatic neoplasm, which accounts for less than 2% of pancreatic malignancy.
This is attributed to the larger amount of aqueous protein within the glandular elements, an abundance of endoplasmatic reticulum of the protein-producing acinar cells, and the high content of paramagnetic ions, such as manganese, within the pancreas.
Acinar cell carcinoma of the pancreas with and without endocrine differentiation.
Two other pancreatic neoplasms that can be included in the differential diagnosis are the uncommon pancreatoblastoma and acinar cell carcinoma.
These are acinar cell carcinomas, (56,57) pancreatoblastomas, (58) and solid-pseudopapillary neoplasms, (59,60) which frequently share the clinical scenario with PENs because of the presence of a slow-growing, pushing mass.
However, this PSA reactivity has also been described in acinar cell carcinoma of the pancreas [8].
65) The pancreatic epithelium contains all the precursor cells of the mature organ and differentiates along islet cell, acinar cell, and ductal cell lineages giving rise to the mature organ.
Sensitivities for specific diagnostic entities were as follows: 79% for ductal adenocarcinoma, 100% for acinar cell carcinoma, 75% for pancreatic endocrine tumor, 70% for intraductal papillary mucinous neoplasms (IPMN), and 42% for mucinous cystic neoplasms (MCN).
Most pancreatic neoplasms are of exocrine type, which includes invasive ductal adenocarcinoma, intraductal neoplasms, pancreatic intraepithelial neoplasms, serous neoplasms, mucinous cystic neoplasms, and acinar cell neoplasms.
Many of the major types of pancreatic neoplasms (ductal adenocarcinoma, pancreatic endocrine neoplasm, acinar cell carcinoma, pancreatoblastoma) typically form solid masses (Figure 4, A and B).
Acinar cell cytoplasm is usually finely granular, light green to gray on Papanicolaou stains and pink to light magenta on air-dried preparations.