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At 2 years, sporadic incidences of acinar adenoma and acinar carcinoma were observed in all dosed groups except those administered 100 ng/kg.
However, many cases are a mixture of high-grade acinar carcinoma and small cell carcinoma.
Furthermore, the prostatic carcinoma in our case was predominantly peripheral, in contrast to the classical periurethral location of prostatic ductal carcinoma, and showed the micropapillary pattern to be intimately admixed with areas of conventional acinar carcinoma.
Although in earlier literature, (3) the term intraductal carcinoma of the prostate has been used variably to describe the extension of prostatic acinar carcinoma, prostatic ductal carcinoma, and urothelial carcinoma into prostatic ducts and acini, currently IDC-P refers to a lumen-spanning proliferation of malignant cells within prostatic ducts and acini caused by the spread of prostate cancer cells within preexisting prostatic glandular structures.
110) An investigation of global microRNA expression patterns in normal pancreas, PENs, and acinar cell carcinomas showed that a particular pattern of microRNA expression distinguishes PEN from normal pancreas and acinar carcinoma, suggesting that this set of microRNAs might be involved in PEN tumorigenesis.