Immunohistochemical antibody cocktail staining (p63/HMWCK/AMACR) of ductal adenocarcinoma and Gleason pattern 4 cribriform and noncribriform acinar adenocarcinomas
of the prostate.
The grade as well as extent of the acinar adenocarcinoma
component in mixed small cell adenocarcinoma in the prostate is variable.
1,3,10) The relative rarity of ductal cancer and its frequent admixture with acinar adenocarcinoma
further complicates its histological recognition.
The diagnosis of ductal and acinar adenocarcinoma
generally depends on histopathologic and immunohistochemical examination.
In conclusion, anatomical and histomorphological findings, and contributions described in the literature allow the tumor to be classified as lung acinar adenocarcinoma
, this pattern of organization was also identified in the nodules collected from the abdominal cavity; suggesting that the primary focus of the neoplasm was from pulmonary origin.
Intraductal carcinoma of the prostate (IDCP) was historically a term used variably to describe prostatic acinar adenocarcinoma
, prostatic ductal adenocarcinoma, and urothelial carcinoma extension into prostatic ducts and acini.
However, when the alveolar architecture is lost and/or myofibroblastic stroma is present, invasive acinar adenocarcinoma
is considered present.
1,2) Among these variants are subtypes of prostatic acinar adenocarcinoma
such as vacuolar, foamy gland, atrophic, and pseudohyperplastic types.
PARTIAL ATROPHY VERSUS PROSTATIC ACINAR ADENOCARCINOMA
Invasive Cribriform Acinar Adenocarcinoma
For example, a significant difference was found for a case for which the evaluation by microscopy and the subsequent staining with cytokeratin 34BE12 verified the presence of a small focus (<1 mm) of prostatic acinar adenocarcinoma
in a biopsy specimen, originally reported as a negative result (case 31).
16-18) Features favoring benign atrophy rather than atrophic-pattern adenocarcinoma include lack of infiltrative pattern of atrophic glands between larger benign glands, lack of coexisting usual acinar adenocarcinoma
with a moderate amount of cytoplasm, and lack of diffuse, significant cytologic atypia in the glands of concern.
The single cytology pleural fluid specimen was an acinar adenocarcinoma
, and the 2 cases of metastasis to lymph nodes (patients 18 and 19) showed mixed subtype adenocarcinoma with papillary, and a small solid pattern in one of the nodes and an acinar pattern in the other.
Differentiation of adenoid cystic/basal cell carcinoma from basal cell hyperplasia and cribriform pattern of acinar adenocarcinoma
may be difficult.
Papillary ductal (endometrioid) adenocarcinoma of the prostate and acinar adenocarcinoma
may present as exophytic papillary proliferation into the prostatic urethra and, therefore, could potentially be seen in urine samples.