Within this class of plant metabolites, only a few of these have been demonstrated to be acetylcholinesterase inhibitors
, including huperzine A, which also has a reported effect on improving memory and learning (Vincent et al.
Nevertheless, considering that serpentine's has: (i) high in vitro potency (IC50 = 0.775 [micro]M) as acetylcholinesterase inhibitor
in comparison with physostigmine (6.45 [micro]M); (ii) a competitive and low affinity interaction with muscarinic receptors ([K.sub.b] = 6.5 [micro]M); and (iii) no neuromuscular nicotinic antagonism up to 100 [micro]M, serpentine may be an interesting lead compound.
N- alkylated galanthamine derivates: potent acetylcholinesterase inhibitors
from Leucojum aestivum.
from the roots of Angelica dahurica.
In their "Recommendations on the treatment of dementia", the Committee on Drugs of the German Medical Profession makes the biased statement: "Of the antidementia drugs discussed here, from the perspective of proven efficacy, the acetylcholinesterase inhibitors
are to be regarded without doubt as the drugs of first choice.
Aricept, originally discovered and developed by Eisai, is an acetylcholinesterase inhibitor
that contains donepezil hydrochloride as its main ingredient, and is the only prescription medicine approved in Japan for the treatment of all stages of AD, from mild through severe.
Akiyama et al., "Donepezil, an acetylcholinesterase inhibitor
against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model," Journal of Molecular and Cellular Cardiology, vol.
The drug is an acetylcholinesterase inhibitor
that scientist believe improves cognitive function by preventing the destruction of acetylcholine, a neutrotransmitter that carries messages in the brain.
Estrogen replacement therapy appears to enhance the cognitive gains associated with the acetylcholinesterase inhibitor
donepezil for some women with Alzheimer's disease, Dr.
All patients must have been taking an acetylcholinesterase inhibitor
for at least 120 days prior to baseline.
* Side effects of acetylcholinesterase inhibitors
can prompt anticholinergic use, which is likely to negate the beneficial effects of the acetylcholinesterase inhibitor
It is thought that the acetylcholinesterase inhibitor
drug, which is used to treat early stages of Alzheimer's, may "switch on" the body's ability to absorb vitamin D2.
Among them, acetylcholinesterase inhibitor
drugs which are maturely-developed relatively occupy five seats.
Yamanishi, "Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor
, " Japanese Journal of Pharmacology, vol.89, no.1, pp.7-20, 2002.