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Clinical limitations of acetylcholinesterase antagonists.

Rangappa, Active Site Directed Docking Studies: Synthesis and Pharmacological Evaluation of Cis-2,6-Dimethyl Piperidine Sulfonamides as Inhibitors of Acetylcholinesterase, Eur.

Thiobencarb-induced changes in acetylcholinesterase activity of the fish Anguilla anguilla.

Partial purification and characterization of acetylcholinesterase (AChE) from the estuarine copepod Eurytemora affinis (Poppe).

Evidence for the presence of soluble acetylcholinesterase insensitive to organophosphat and carbamat inhibitors.

Effect of diazinon on acetylcholinesterase activity and lipid peroxidation of Poecilia reticulate.

Acetylcholinesterase breaks down acetylcholine into acetate and choline, both of which are difficult to detect.

In this respect, we initiated the study of some species belonging to this family with habitats in Brazil; the results of our previous studies showed a promising in vitro inhibiting effect upon acetylcholinesterase activity (Konrath et al.

Different sensitivity to organophosphates of acetylcholinesterase and butyrylcholinesterase from three-spined stickleback (Gasterosteus aculeatus): application in biomonitoring.

Inhibitory effects (%) of the extracts of lyophilized biomass taken from Lake Ladoga water blooms on cell viability (cytotoxic activity) and on trypsine and acetylcholinesterase activities (-, no data) Assay Stations in Lake Ladoga 87 92 4 6 17 Cytotoxic activity - - 50 50 50 Trypsine inhibition activity 93 68 93 96 99 Acetylcholinesterase inhibition activity - - 27 26 31 Table 2.

In animal models, developmental neurotoxicity results from either CPF or DZN at doses that do not elicit any signs of systemic intoxication and even at exposures below the threshold for inhibition of acetylcholinesterase (AChE), which is often considered to be the primary target for OPs (Slotkin 1999, 2004, 2005; Slotkin et al.

About 75% of the patients were taking acetylcholinesterase inhibitors, which were continued throughout the study.

The nerve agents cause toxicity by binding to and inhibiting acetylcholinesterase, an enzyme in the body that is essential for nervous system function, leading to increases in acetylcholine and "cholinergic crisis" that can cause loss of muscle control, respiratory failure, paralysis, convulsions, permanent brain damage and eventually death, according to PharmAthene Inc.

About 75% of the patients were on acetylcholinesterase inhibitors, which were continued throughout the study.

Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, Israel) have patented an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme.