Accordingly, we protected the hydroxyl groups of RES from metabolism by acetylating them and synthesized 3,5,4'-tri-O-acetylresveratrol (TARES, Fig.
TARES is a prodrug of RES by acetylating its three hydroxyl groups.
Table 2 describes protection of 1-butanol with different acetylating agents catalyzed by [H.
1]) Table 2: Protection of 1-butanol to the corresponding acetate with different acetylating agents catalyzed by [H.
The observed effect of reduction in paste viscosity at low degree of acetylating
is consistent with prevention of close association of chains due to steric hindrance effect of the acetyl groups.
Today, the preferred method of acetylating
wood is to use a limited amount of liquid acetic anhydride without a catalyst or cosolvent.
Three concentrations (0,25 M, 0,50M and 1M) and two times of treatment (30 and 60 minutes) during acetylating
process was tested.
In vitro, SOHA induces differentiation and apoptosis in a variety of tumor cell lines by acetylating
histone proteins, thereby promoting normal DNA transcription.
A second abstract entitled "Pharmacodynamic effect of MGCD0103 on histone deacetylase (HDAC) enzyme inhibition and histone acetylating
induction in Phase I clinical trials in patients with advanced solid tumours or non-Hodgkin's lymphoma" disclosed novel methods used to monitor the pharmacodynamic effect of MGCD0103 in clinical samples and outlined the positive correlation between HDAC enzyme inhibition, determined using MethylGene's proprietary Whole Cell assay, and histone acetylation in peripheral white cells from patients treated with MGCD0103.
Evidence is presented here that human leukemia cells are capable of acetylating