Accordingly, we protected the hydroxyl groups of RES from metabolism by acetylating them and synthesized 3,5,4'-tri-O-acetylresveratrol (TARES, Fig.
TARES is a prodrug of RES by acetylating its three hydroxyl groups.
Table 2 describes protection of 1-butanol with different acetylating agents catalyzed by [H.
1]) Table 2: Protection of 1-butanol to the corresponding acetate with different acetylating agents catalyzed by [H.
A second abstract entitled "Pharmacodynamic effect of MGCD0103 on histone deacetylase (HDAC) enzyme inhibition and histone acetylating
induction in Phase I clinical trials in patients with advanced solid tumours or non-Hodgkin's lymphoma" disclosed novel methods used to monitor the pharmacodynamic effect of MGCD0103 in clinical samples and outlined the positive correlation between HDAC enzyme inhibition, determined using MethylGene's proprietary Whole Cell assay, and histone acetylation in peripheral white cells from patients treated with MGCD0103.
Evidence is presented here that human leukemia cells are capable of acetylating
Because of the cost of acetylating
wood, acetylated wood will find applications in value-added products.
The observed effect of reduction in paste viscosity at low degree of acetylating
is consistent with prevention of close association of chains due to steric hindrance effect of the acetyl groups.
Firstly, an additional 5 mg/kg dose of INH should be added to the recommended fixed-drug combination during the intensive stage of therapy because of fast acetylating
of INH in childhood.