Heard, "Acetylcysteine for acetaminophen poisoning
," The New England Journal of Medicine, vol.
However in the present study the median hospital stay was prolonged because of the high frequency of acetaminophen poisoning
that required N-acetylcysteine treatment and the prolonged hospital stay required for patients with carbon monoxide intoxication.
The classic method for treating acetaminophen poisoning
is to use N-acetylcysteine.
Nephrotoxicity after acute severe acetaminophen poisoning
12-14) Although it is clear that acetylcysteine is an effective antidote for acetaminophen poisoning
, (15-18) specific criteria defining those at risk for hepatotoxicity or even attributing enzyme abnormalities to acetaminophen are not clear.
Ingestion of higher doses, however, can lead to acetaminophen poisoning
with hepatotoxicity (10-15 g/day) and maybe fatal (20-25 g/day).
The toxicity caused by this single drug is completely unnecessary, since the antidote to acetaminophen poisoning
is a sulfur compound you can find in any health food store called NAC (N-acetyl cysteine).
Merck manual's online medical library, acetaminophen poisoning
Targeting the hospital acute care and gastroenterology segments, Cumberland's portfolio is comprised of two products--Acetadote, for the treatment of acetaminophen poisoning
, and Kristalose, a prescription strength laxative approved by the FDA.
About 56,000 Americans visit emergency rooms each year due to acetaminophen poisoning
(most of the time, the overdose is unintentional).
According to the American Association of Poison Control Centers, in 2003 more than 65,000 patients were seen in health care facilities for potential acetaminophen poisoning
, and 327 died.
Patients with acetaminophen poisoning
can have transaminase levels over 3,500 U/L.
Liver toxicity from Acetaminophen poisoning
is the number one cause of acute liver failure in the United States, according to researchers reporting in the December issue of Hepatology.