Aladoteis a 'first-in-class' drug candidate that is being developed to reduce liver damage due to acetaminophen poisoning
. A proof of principle study (POP), phase Ib / IIa has been successfully completed and the design of the next study is being finalized.
Acetylcysteine for acetaminophen poisoning
. N Engl J Med.
Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral acetylcysteine for treatment of acute acetaminophen poisoning
. Am J Ther.
The classic method for treating acetaminophen poisoning
is to use N-acetylcysteine.
Nephrotoxicity after acute severe acetaminophen poisoning
Refining the level for anticipated hepatotoxicity in acetaminophen poisoning
. J Emerg Med.
Specialist pharmaceutical company Cumberland Pharmaceuticals Inc (Nasdaq:CPIX) revealed on Thursday the receipt of approval from the US Food and Drug Administration (FDA) for a new formulation of Acetadote (acetylcysteine) Injection for the treatment of acetaminophen poisoning
Each year, acetaminophen poisoning
results in 100,000 calls to poison control centers, 56,000 emergency room visits, 26,000 hospitalizations, and more than 450 deaths from liver failure.
Cumberland's product portfolio includes Acetadote(r) (acetylcysteine) Injection for the treatment of acetaminophen poisoning
and Kristalose(r) (lactulose) for Oral Solution, a prescription laxative.
Laboratory tests were repeated and results were consistent with significant hepatocellular damage secondary to acetaminophen poisoning
, including increased AST of 11 000 U/L (reference interval 8-48 U/L), ALT of 6510 U/L (reference interval 7-55 U/L), total bilirubin of 395 [micro]mol/L (23.1 mg/dL) [reference interval 2-17 [micro]mol/L (0.1-1.0 mg/dL)], and direct-bilirubin of 207 [micro]mol/L (12.1 mg/dL) [reference interval <5.0 [micro]mol/L (<0.3 mg/dL)].
The toxicity caused by this single drug is completely unnecessary, since the antidote to acetaminophen poisoning
is a sulfur compound you can find in any health food store called NAC (N-acetyl cysteine).
Merck manual's online medical library, acetaminophen poisoning
. Retrieved November 2, 2006, from http://www.merck.com/mmpe/sec21/ch326/ch326c.htmI#BGBHFGBA
Targeting the hospital acute care and gastroenterology segments, Cumberland's portfolio is comprised of two products--Acetadote, for the treatment of acetaminophen poisoning
, and Kristalose, a prescription strength laxative approved by the FDA.
About 56,000 Americans visit emergency rooms each year due to acetaminophen poisoning
(most of the time, the overdose is unintentional).
According to the American Association of Poison Control Centers, in 2003 more than 65,000 patients were seen in health care facilities for potential acetaminophen poisoning
, and 327 died.