(52) The lesions are acanthotic
and may appear psoriasiform or slightly verruciform (Figure 6, A).
Caption: Figure 2: (a, b) Regular acanthotic
epidermis, a dense dermal infiltrate of pleomorphic atypical lymphoid cells, and destruction of the blood vessels' walls by abnormal lymphocytes.
Microscopically, these changes result from fibroblast proliferation, thickening, and packing of collagen fibers resulting in acanthotic
dermis as well as endothelial cell hyperplasia leading to partial occlusion of the blood vessel lumen.
Punch biopsy taken from a lesion was sent to histopathological examination, which revealed deep, wide invagination of acanthotic
epidermis, filled with concentric lamellae of keratin but absence of hair shafts (Figure 2).
The light microscopic examination revealed squamous cell carcinoma (SCC) as acanthotic
squamous epithelium with deep rete pegs, epithelial and keratin pearls, pleomorphism, stromal infiltration and hyperchromatic nuclei (Fig.
Nearly all precancerous lesions (leukoplakia, erythroplakia and lichen planus) in their histology shows acanthotic
change but it is reactive in nature in most of the cases.13 Similar changes were noted in studies performed by Mohamed and Rita in 1997 in Egypt and Swad in 2009 in Iraq, however, rats and rabbits were used as experimental animals respectively.14,15
Out of 20 cases of ameloblastoma, thirteen (65%) were of follicular and plexiform with equal frequency, two (10%) were of granular cell variant, two (10%) were arising in the dentigerous cyst, two (10%) were of acanthotic
variant with squamous differentiation and one (5%) was of unicystic ameloblastoma.
Subjacent epidermis was atrophied; acanthotic
septae and papillary projections were overlain by orthokeratotic spires separating pouches.
In histopathology view, hyperkeratinized and acanthotic
squamous epithelium with or without cellular vacuolization or edema of Glycogen-rich cells are seen.
Both the histopathological findings revealed features of surface ulceration, acanthotic
epidermis with focal areas of inflammatory infiltration predominantly neutrophils, with increased number of small vessels arranged back to back and feeding into larger vessels.
In the infantile stage the epidermis is only slightly acanthotic
and may be hyperpigmented.
Histopathology revealed a hyperkeratotic and acanthotic
epidermis with an intraepidermal pustule with luminal aggregates of neutrophils and nuclear debri overlying granulation tissue.
OLP lesions are likely to be more atrophic than acanthotic
as compared to CLP .
Biopsy section showed hyperkeratotic and acanthotic
The endophytic component showed deep acanthotic
growths with a periphery of mitotically active basaloid cells and variable atypical squamous cells with frequent atypical mitoses.