Hyperinsulinemia and acanthosis
nigricans in African Americans [see comments] Journal of National Medical Association, 89(8), 523-7.
78.5% had a family history of the disease, 74.2% were overweight, and 48% had acanthosis
Kendall Little Owl shows indications of acanthosis
may assume a saw-toothed appearance.
nigricans was detected in an 85.9% of the children with obesity and in 36% of the children with normal weight (P < 0.001).
A 5-year-old female patient was referred due to acanthosis
nigricans and generalized lanugo which developed in the last two years.
Histopathology reveals findings similar to those that may be found in acanthosis
nigricans and epidermal nevi.
Hyperkeratosis and acanthosis
were more prominent in lichen amyloidosis compared to macular amyloidosis.
Histopathology shows pseudoepitheliomatous hyperplasia with marked hyperkeratosis, acanthosis
, and dense inflammatory infiltrates with epithelioid cells and giant cells in the mid-dermis.
The invasive acanthosis
and cellular atypia can make it difficult to distinguish this lesion from squamous cell carcinoma (Lloyd, 1997).
Differential diagnosis includes acanthosis
Findings in early lesions may be nonspecific and may include mild acanthosis
, papillary dermal oedema and lymphocyte-predominant dermal infiltrate.
Besides PEO, DCS has also been observed in angio-immunoblastic lymphoma, (2) cutaneous Waldenstrom's macroglobulinemia, (3) acanthosis
nigricans, (1,4) erysipelas, discoid lupus and acute contact dermatitis.
Waist Hip Ratio (WHR) was raised in 42 (91.30 Percent), acanthosis
was found in 26(56.50 Percent), impaired FBS was seen in 9 (19.6 Percent) and raised fasting insulin in 16 (34.8 Percent) patients.
These patches, known as acanthosis
nigricans, could be benign or a normal side effect of obesity, but they also could be a sign of diabetes, said dermatologist Janet Lin of Baltimore's Mercy Medical Center.