(a) Data set Training Validation Test Normal 728 81 203 Echinocyte 226 25 63 Dacrocyte 64 7 18 Schistocyte 546 61 152 Elliptocyte 66 7 18 Acanthocyte
120 13 33 Target cell 523 58 145 Stomatocyte 79 9 22 Spherocyte 173 19 48 Overlap 166 18 46 (a) Cells were randomly distributed 80:20 between training and test sets, respectively.
is a genus of agaricoid, mushroom-forming fungi, which are characterized by the presence of partial veil usually forming an annulus or leaving remnants at the pileus margin, adnate to adnexed lamellae and well-developed rhizomorphs on stipe base, which are densely covered by spiniform crystals called acanthocytes
, the latter considered a diagnostic feature of the genus (Farr, 1980; Cortez & Silveira, 2008).
In the interest of simplifying reports and eliminating redundant information given to clinicians, some laboratories have moved to eliminating the non-specific term poikilocytosis and reporting only the specific type of abnormal RBC forms, (2) such as spherocytes, acanthocytes
, and teardrops.
Caption: Peripheral Smear (100x) showing Acanthocytes
in a Case of Liver Disease
For diagnosing neuroacanthocytosis syndromes, detection of acanthocytes
in the peripheral blood is an important criterion; however, since the presence of acanthocytosis alone is not significant, there should be accompanying clinical findings (4).
For morphological analysis, abnormal erythrocyte morphology such as stomatocytes, acanthocytes
, schistocytes, and dacryocytes could be observed following pristane injection.
The presence of acanthocytes
is evidenced as abnormal projections on the red blood cells.
The causes of thrombocytosis could be multiple such as myeloproliferative disorders, reactive or secondary thrombocytosis or Hyposplenism or Post splenectomy.2 Hyposplenism (or asplenia or autosplenectomy) is defined as underfunctioning of the spleen which may or not be associated with a reduction in splenic size.3 The normal functions of the spleen are reduced to a varying degree in a number of illnesses including systemic lupus.3 Hyposplenism is characterized clinically by leukocytosis, thrombocytosis, presence of Howell jolly bodies, erythrocytes pits and acanthocytes
on peripheral smear.
Marked changes in the shape of RBC from normal discocytes to echinocytes, spherocytes, stomatocytes and acanthocytes
were also observed in the blood of the rats treated with (131)I.
Poikilocytosis is moderate to severe with burr cells, acanthocytes
, and schistocytes present.
Crenated erythrocytes can also resemble acanthocytes
that are associated with certain lipid disorders.
rugosoannulata J2 were trapped by acanthocytes
which can be seen in Fig.
Neuroacanthocytosis is a cause of chorea in children and can be diagnosed by a fresh peripheral blood smear examination showing acanthocytes
in the smear.
Our patient, however, showed no evidence of malabsorption, retinitis pigmentosa, or neurologic disease, and there was no evidence of acanthocytes
. The mild clinical phenotype strongly suggested the clinical diagnosis of heterozygous FHBL.