7) Ocular melanocytosis is a developmental condition in which the ocular surfaces and the uveal tract
are hyperpigmented; it is called oculodermal melanocytosis or nevus of Ota when it involves the skin of the eyelids and face.
The tumors arise from pigment cells, called melanocytes, that reside in the layer below the retina called the uveal tract
Generally, they reach the uveal tract
leading to moderate to severe uveitis and intraocular hemorrhage or hypopion (Figure 1F); however, infiltration of the cornea is also possible.
However, it has become clear [it] is a systemic disease that can involve joints, gut mucosa, the uveal tract
, and the endothelium, with associated cardiovascular and vascular issues.
Extraintestinal manifestations are protean, and they typically involve the joints, perianal tissues, and uveal tract
Ocular metastases are hematogenously disseminated and most commonly affect the uveal tract