Studying the essential interplay between melanoma and tumor-infiltrating lymphocytes
, Markel et al.
In this article, we describe our investigation into whether the number of CD3-positive tumor-infiltrating lymphocytes
is correlated with clinical outcome in a cohort of patients with oropharyngeal cancer in general and HPV-associated HNSCC in particular.
In sum, cimetidine appears to support cellular immunity via several mechanisms, including blocking the immunosuppressive effect of histamine, inhibiting suppressor T-cell activity, increasing the number of tumor-infiltrating lymphocytes
, and boosting the activity of peripheral blood lymphocytes.
Prognostic value of tumor-infiltrating lymphocytes
in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.
Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes
are correlated with the progression of human cervical carcinoma.
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes
Velotti F, Chopin D, Gil-Diez S, Maille P, Abbou CC, Kourilsky P, et al Clonality of tumor-infiltrating lymphocytes
in human urinary bladder carcinoma.
The James' researchers chose not to use tumor-infiltrating lymphocytes
for a good reason.
In this Special Focus issue, we discuss the immune cross-talk driven by natural killer cells, the split personality of NKT cells and macrophages in malignancy, autoimmune disorders and infectious disease, the two-sided roles of dendritic cells in the pathogenesis and treatment of human disease, the pleiotropic functions of naive, effector and memory CD8 T cells and tumor-infiltrating lymphocytes
, and how lymphocyte function may be influenced by the stromal cell network affecting the inflammatory process.
A growing set of clinical and preclinical data have demonstrated the ability of G100 to activate tumor-infiltrating lymphocytes
, macrophages and dendritic cells, and promote antigen-presentation and the recruitment of T cells to the tumor.
37) Quantitation of tumor-infiltrating lymphocytes
may be important in breast carcinoma prognostics and theranostics (38); and as we have shown with on-slide "flow cytometry" methods for counting lymphocytes on WSIs, (39-41) IA may be useful in quantitating tumor-infiltrating lymphocytes
in breast cancer.
The in vivo data show that treatment of HER2-positive tumor-bearing animals with PRS-343 provided dose-dependent, dual anti-tumor activity by increasing the frequency of tumor-infiltrating lymphocytes
via bispecific targeting of 4-1BB and HER2, as well as mediating tumor growth inhibition by direct antagonism of HER2 on tumor cells.
Studies conducted by the National Cancer Institute of adoptive transfer of in vitro-selected tumor-infiltrating lymphocytes
were the first to demonstrate the potential of T-cell immunotherapy to eradicate solid tumors.
In addition to a determination of the recommended Phase 2 dose, the study will assess preliminary anti-tumor activity, including objective response rate (ORR),the immunologic effect of NKTR-214 on tumor-infiltrating lymphocytes
(TILs) and other immune infiltrating cells in both blood and tumor tissue, concluded the company.
Checkpoint inhibitors may be more active in patients with baseline tumor-infiltrating lymphocytes
(TILs) and tumor PDL1 expression.