In sum, cimetidine appears to support cellular immunity via several mechanisms, including blocking the immunosuppressive effect of histamine, inhibiting suppressor T-cell activity, increasing the number of tumor-infiltrating lymphocytes
, and boosting the activity of peripheral blood lymphocytes.
It is well documented that HPV-positive patients tend to have better clinical outcomes than do HPV-negative patients, (6) and we attempted to determine whether tumor-infiltrating lymphocytes
may play a role in that difference.
Adaptive immunotherapy using lymphokine-activated killer cells and tumor-infiltrating lymphocytes
The importance of T-cells in cancer has long been recognized, but we now have a better understanding of how tumor-infiltrating lymphocytes
(TILs) can affect tumor control and prognosis in patients with melanoma," said Mule.
No tumor-infiltrating lymphocytes
, peritumoral chronic inflammation, Crohn disease-like peritumoral lymphocytic reactions, or residues of a preexisting adenoma were noted.
gene expression profiling and immunohistochemistry for tumor-infiltrating lymphocytes
(TILs); duration of response to treatment; overall survival; progression-free survival; and safety.
PD-1 expression on tumor-infiltrating lymphocytes
was seen in 48% and was higher in GBM than grade II-III.
El-Deiry and colleagues presented data suggesting that PD-1/PD-L1 protein expression is inversely associated with KRAS mutation status in patients with microsatellite instability high (MSI-H) colorectal cancer (CRC), a tumor sub-type that comprises roughly 15% of CRC cases and is characterized by higher expression of PD-1 in tumor-infiltrating lymphocytes
compared to non-MSI-H (abstract #152887).
The poster presentation will discuss the unmet medical need of "anti-PD-1 non-responders," which are characterized by the absence of immune cells, and the role of interventions that are specifically focused on increasing tumor-infiltrating lymphocytes
Abstract #2856 : Unique changes in the TCR repertoire of tumor-infiltrating lymphocytes
underlie the synergy of radiotherapy with CTLA-4 blockade Presenter: Karsten Pilones Session: Mini-symposium: Immune Checkpoint Inhibition Time : Monday, April 20, 2015, 3:20 PM -- 3:35 PM Location : Terrace Ballroom IV (400 Level), Pennsylvania Convention Center
(TILs) from this model have enhanced survival and decreased PD-1 expression.
Additionally, of the nine patients whose tumor samples were examined for presence of the programmed cell death protein 1 (PD-1) and its ligand, PD-L1, 56% exhibited positive tumor-infiltrating lymphocytes
(TILs) and 33% exhibited PD-L1 tumor expression, suggesting the potential viability of targeted agents that inhibit these immune regulatory checkpoints.
The authors analyzed the distribution of PD-1-positive tumor-infiltrating lymphocytes
(TILs) and cancer cell expression of PD-L1 in 437 tumor samples (380 carcinomas, 33 sarcomas, 24 melanomas).
CLEVELAND, May 14, 2014 /PRNewswire/ -- Researchers from University Hospitals (UH) Case Medical Center's Seidman Cancer Center will present findings from a study that found the presence of tumor-infiltrating lymphocytes
, a type of white blood cell, ahead of treatment may help predict response to platinum-based chemotherapy in women with triple-negative breast cancer.
In the study, these technologies were utilized to count and determine the density of tumor-infiltrating lymphocytes
(TILs) in ovarian cancer.