5], This study, therefore, evaluated the levels of lactate and glucose-6-phosphate-dehydrogenases, Acid and Alkaline Phosphatases, Alanine and Aspartate Transaminases
in the sera of Nigerians affected with hematological malignancies, to determine if these enzymes could be established as predictors of possible metastasis to the liver, type, or the degree of severity of the disease or even prognostication of hematological malignancies.
Multiple studies have uncovered evidence that transaminases
need not be elevated in abnormal ranges to be indicators of liver disease.
It's still a tricky issue, as one of the purposes of following the labs, such as liver function tests, is to see if there are individuals with high-grade transaminase
In eight cases, the initial transaminase
increase was interpreted as a DAA drug reaction and the medicine was discontinued.
Another interesting complication of hypoxia in this case is the associated hypoxic hepatitis as evidenced by the marked rise in transaminases
(SGOT: 3,093 units/L, SGPT: 1,573 units/L) and the fall in transaminases
by 50% within 72 h.
Several causes can lead to increased levels of the transaminases
including infectious, metabolic, toxic, inflammatory, infiltrative, and traumatic causes.
Although relation of bile acid level with severity of disease and its outcome have been studied but in this part of world serum transaminases
levels are done to establish the diagnosis and extent of disease.
In group III, bilirubin level was increased and alanine transaminase
was decreased significantly (pless than 0.
Intolerance was defined as an increase of CPK >3-10 times the upper limit normal (ULN), and/or a rise in transaminases
values >3-5 times ULN, and/or the onset of asthenia, myalgia or rhabdomyolysis whilst on actual statin dosage.
Rare late AEs (1 patient each) included hair loss, skin rash, myelosuppression and persistent transaminases
(elevated liver enzymes).
For the purpose of the study, any level of elevation of transaminases
or bilirubin above the normal values was considered as hepatic abnormality and was further reviewed.
Among the topics are synthesizing chiral amines using transaminases
, developing a sitagliptic transaminase
, olefin metathesis from academic concepts to commercial catalysts, the discovery of a new palladium/copper catalytic system for carbon-hydrogen arylation and its applications in a pharmaceutical process, and catalytic variants of phosphine oxide-mediated organic transformations.
Elevation of hepatic transaminases
in plasma is observed in up to 40% of patients and often occurs asymptomatically during the first several months of therapy.
There was no reason which could lead to elevation of transaminases
derived from liver.
Concentrations of serum transaminases
in acute hepatitis increased with age and peaked at 7-8 years, having a median of 1565 (minimum: 9 and maximum: 4014) for AST and 1942 (minimum: 22 and maximum: 3950) for ALT.