agents and the incidence of hip fracture.
The study by Williams et al--a double-blind, randomized placebo-controlled crossover trial conducted in the UK--was the first RCT to directly compare spironolactone with other medications for the treatment of resistant hypertension in adults already on triple therapy with an ACE inhibitor or ARB, a CCB, and a thiazide diuretic
7 Thiazide Diuretics
To assess therapeutic effectiveness of thiazide diuretic
therapy, nurses should monitor patients' intake and output as well as blood pressure (Adams et al.
The three metabolic adverse events that researchers assessed were hyponatremia (low sodium levels in the blood), hypokalemia (low potassium levels in the blood), and acute kidney injury (a 25 percent decrease in kidney function from the baseline value before the thiazide diuretic
Consider a thiazide diuretic
if patients are intolerable to any of the above (3).
The null hypothesis of the parent study is that financial incentives would not significantly increase the number of patients who discussed thiazide diuretics
with their primary care providers--and the null hypothesis was not disproved.
The study included 33,000 people who were randomized to take one of three blood pressure-lowering medications: a thiazide diuretic
, a calcium-channel blocker, or an ACE inhibitor.
Niacin (Niacor, Niaspan, Slo-Niacin) in combination with a thiazide diuretic
Briefly, 33,000 patients were randomly studied using chlorthalidone, a thiazide diuretic
available generically; amlodipine (Norvasc); lisinopril (Prinivil); and doxazosine (Cardura).
Head Office: Tokyo; President and CEO: Yoshihiko Hatanaka, hereafter Astellas) announced that manufacturing and marketing approval for Micatrio Combination Tablets, a combination of Micardis Tablets (AT1 receptor blocker ARB ), long-acting calcium channel blocker (CCB) amlodipine besylate and the thiazide diuretic
hydrochlorothiazide (HCTZ) was obtained on September 28.
African Americans should begin treatment with a thiazide diuretic
or calcium channel blocker.
The study compared 1,060 older adults with high BP who recently began taking a thiazide diuretic
with a similar group who were not prescribed a thiazide diuretic
The JNC 8 writers suggested doctors choose from an angiotensin-converting enzyme inhibitor (ACEI, such as Altace, Vasotec, Lotensin), angiotensin receptor blocker (ARB, such as Benicar, Diovan), calcium channel blocker (CCB, such as Norvasc, Procardia) or thiazide diuretic
(such as Esidrix or Zaroxolyn).