Metformin-which targets both insulin resistance and hepatic glucose production-has largely replaced the sulfonylureas
as first-line monotherapy.
Studies show a substantial number of patients taking Rezulin as initial therapy or in combination with sulfonylureas
or insulin can reach American Diabetes Association (ADA) targets for blood glucose control.
For several years now, conventional wisdom has regarded sulfonylureas
as the second-line oral agent--because of their efficacy, long track record, and availability as low-cost generics--to use after metformin for patients with type 2 diabetes who need drug treatment for hyperglycemia.
can cause hypoglycemia and weight gain
MEPs objected, by 430 votes to 188, with 33 abstentions, to a European Commission implementing decision in which it proposed to authorise the import, distribution and retailing in the EU of cut flowers of the genetically modified (GM) carnation SHD-27531-4, which is resistant to sulfonylurea
herbicide, for ornamental use.
Patients with type 2 diabetes mellitus treated with metformin as a monotherapy are at a decreased risk for cardiovascular mortality when compared with those on sulfonylurea
Patients with type 2 diabetes treated with metformin as a monotherapy are at a decreased risk for cardiovascular mortality, compared with those on sulfonylurea
monotherapy, according to a report in the Annals of Internal Medicine.
In the RCTs, the hazard ratios comparing sulfonylureas
to all treatments combined were 1.
Metformin, which does not stimulate insulin, is still the cornerstone of initial therapy but sulfonylureas
are losing their utility and popularity.
Oral alternatives to metformin included the sulfonylureas
, pioglitazone, alpha-glucosidase inhibitors and gliptins.
The study included 78,241 diabetics treated with metformin and 12,222 prescribed sulfonylureas
, matched with 90,463 nondiabetic control subjects.
TEHRAN (FNA)- Patients diagnosed with diabetes and initially prescribed metformin to lower their glucose levels were less likely to require treatment intensification with a second oral medicine or insulin than patients treated first with sulfonylureas
, thiazolidinediones or dipeptidyl peptidase 4 inhibitors, according to a study.
are insulin secretagogues used in type 2 diabetes mellitus.
In a recent study comparing the effectiveness of sulfonylureas
and metformin as first-line treatments of diabetes, metformin was associated with more positive outcomes.
Researchers evaluated "data from nearly 24,000 patients with type 2 diabetes, average age 62, who were treated with one of three drugs called sulfonylureas
(glipizide, glyburide, and glimepiride) or with another type of drug called metformin.