High lung exposure following inhalation of a single dose of 20 mg Pulmazole was maintained over a 24-hour period, whereas sputum concentrations of itraconazole decreased between 2 hours and 6 hours after a single 200 mg oral Sporanox
This product is the generic version of Janssen Pharmaceutical Inc.'s Sporanox
and is indicated for the treatment of fungal infections that begin in the lungs, blatsomycosis, histoplasmosis, and aspergillosis in patients who are intolerant of or who are refractory to amphotericin B therapy.
The most potent medical treatments are potentially toxic anti-fungal drugs taken by mouth, such as Ketoconazole, Lamisil (again), Sporanox
Drugs associated with moderate (50%-80%) inhibition of 17P were fluconazole (Diflucan), itraconazole (Sporanox
), diltiazem, esomeprazole (Nexium), tacrolimus, and bergamottin.
Drugs shown to be weakened by orange and apple juice (as well as boosted by grapefruit juice), include beta blockers such as atenolol (Tenormin), which is used to treat high blood pressure; the anti-cancer drug etoposide (Etopophus); cyclosporine (Neoral), which is used to prevent organ rejection after transplants; and some antibiotics, including cipro-floxacin (Cipro) and itraconazole (Sporanox
He said that Itraconazole (brand name Sporanox
) and Fluconazole (brand name Flucan or Diflucan) are safer alternatives to treat fungal infection over a longer time without having side effects on the liver.
Itraconazole is marketed under the brand name Sporanox
by Johnson & Johnson (New Brunswick NJ) unit Janssen Pharmaceutica, mostly for treating a fungal infection called aspergillus.
itraconazol formulation from Janssen has pioneered this technology and is available in injectable and oral dosage forms.
For example, some antifungal medications such as itraconazole (SPORANOX
) and ketoconazole (NIZORAL) can interfere with the way some cholesterol-lowering medications are broken down by the body.
) is currently not FDA-approved to treat tinea capitis, but it is approved to treat onychomycosis and fungal infections of the esophagus and mouth (Deglin & Vallerand, 2009).
Other tests showed juices can affect the absorption of anti-cancer drugs such as etoposide (Etopophos, Vepesid), beta blockers such as tenormin (Atenolol) and talinolol (Cordanum), and antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin) and itraconazole (Sporanox
He or she may prescribe an oral antifungal medication--such as fluconazole (Diflucan), itraconazole (Sporanox
) or terbinafine (Lamisil)--that allows your new nail to grow infection-free and slowly replace the infected part of your toenail.
A meta-analysis comparing the efficacy of terbinafine (Lamisil), pulse-dosed and continuous-dosed itraconazole (Sporanox
), fluconazole (Diflucan), and griseofulvin showed mycological cure rates of varying degrees for each treatment (TABLE).
In addition, if combined with Sustiva, the following drugs may require a change in the dose of either Sustiva or the other medicine: Ritadin (ritampin); Sporanox
(itraconazole); Nizoral (ketoconazole); calcium-channel blockers (for example, Cardizem, Tiazac, and others); and the cholesterol-lowering medications Lipitor (atorvastatin), Pravachol (pravastatin), and Zocor (simvastatin).
Some studies have documented good response rates with itraconazole (Sporanox
) and fluconazole (Diflucan).