But Waxman is part of a cadre of researchers hunting for ways to target just one key sodium channel
The protein expression of sodium channel
in SG was determined by immunohistochemical analysis.
Dietary salt regulates epithelial sodium channels
in rat endothelial cells: adaptation of vasculature to salt," British Journal of Pharmacology, vol.
ROS can downregulate cardiac sodium channels
and mitochondrial antioxidants can reverse this effect .
This work shows how chloride transporters can work with sodium channels
in cell membranes to cause an influx of salt into a cell," said Philip Gale, study co-author professor from the University of Southampton in Britain.
Drug Mechanism Carbamazepine Inhibits voltage-dependent sodium channels
; [gamma]-aminobutyric acid (GABA) agonist Gabapentin Increases release of GABA Decreases release of glutamate Modulates voltage-dependent calcium channels Lamotrigine Decreases release of glutamate Modulates sodium, potassium, and calcium channels Oxcarbazepine Inhibits voltage-dependent sodium channels
; GABA agonist Phenytoin Inhibits voltage-dependent sodium channels
; GABA agonist Topiramate Increases release of GABA Decreases release of glutamate Precise mechanism of action is unknown Valproate Increases GABA activity Inhibits N-methyl-D-aspartate activity Modulates voltage-dependent sodium channels
Acts on sodium channels
thereby blocking release of glutamate (excitatory neurotransmitter)
These proteins, called sodium channels
, operate tiny gates to control the flow of sodium into the cell.
In 1998, a hereditary (autosomal dominant) gene defect was found, involved in the coding of protein components in the sodium channels
in heart cells.
Stretch modulates amiloride sensitivity and cation selectivity of sodium channels
in human B lymphocytes.
Aim: Epithelial sodium channels
play an important role in the regulation of movement of sodium and absorption of alveolar fluid during prenatal period.
The receptor-hormone complex activates intracellular signaling cascades, increasing the luminal epithelial sodium channels
in many organs, including kidney, lung, colon, and sweat and salivary glands.
The salt acts to refuel the sodium channels
in the fish's muscle - allowing it to spasm- as long as the bones, spine and muscle are attached.
The University of Leeds research team found that the gas kept sodium channels
, which are important for controlling the heartbeat, open for longer.
In an early but seminal discovery, Waxman showed that MS patients in remission experience redistribution of sodium channels
to areas of myelin damage, which provides a way for nerve signals to be transmitted.