EFSA FEEDAP Panel EFSA Panel on Additives and Products or Substances used in Animal Feed, "Scientific opinion on the safety and efficacy of selenium compounds
(E8) as feed additives for all animal species: sodium selenite (coated granulated preparation), based on a dossier submitted by Doxal Italia S.p.A," EFSA Journal, vol.
First data came from the Nutritional Prevention of Cancer (NPC) study, which indicated that selenium compounds
have chemopreventive properties, but then the SELECT study has reported debate on the issue (34).
Control NMR data are cell samples without selenium compounds
Control cells and those exposed to selenium compounds
were fixed with 4% pformaldehyde for 20 min, permeabilized with 0.05% Triton buffer containing 10 mM Tris, 5mM KCl, and 1mM Mg[Cl.sub.2], and later exposed to anti-[beta]-Tubulin/anti-mouse IgG-FITC antibodies or FITC-phalloidin (Sigma Aldrich).
are generally very efficiently absorbed by humans, and selenium absorption does not appear to be under homeostatic control6.
Fractionation and identification of the major selenium compounds
in selenized yeast.
"There are EU rules on the kinds of selenium compounds
and limits on the amounts that can be added to feeds.
Other studies published in the journals Carcinogenesis and Cancer Prevention Research have explored the role of organic selenium compounds
in killing human prostate and colon cancer cells.
There are a wide range of selenium compounds
in high-selenium yeast, some of which have not yet been identified.
High-selenium yeast contains several different natural anabolic and catabolic forms of organically-bound selenium in addition to SeMet, such as selenocysteine, methylselenocysteine, and several other selenium compounds
, all organically bound.
The content of other organic selenium compounds
, including selenocysteine, does not exceed 10%.
Nearly all selenium compounds
contribute to the body's nutritional needs for selenium and its defense against cancer.
Limburg, M.D., of the Mayo Medical School, Rochester, Minn., and his colleagues conducted a randomized, double-blind, placebo-controlled trial of two promising selenium compounds
: selenomethionine (a synthetic form of organic selenium) and celecoxib (a selective inhibitor of cyclooxygenase-2) among residents of Linxian County, People's Republic of China (Gastroenterology 2005;129:863-73).
Species-selective determination of selenium compounds
in biological materials.
Other selenium compounds
have been found to cause nausea, headaches, dizziness, rashes, respiratory problems and even cancer.