ALS

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Related to SOD1: SOD2, SOD3, G93A
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Synonyms for ALS

thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord

References in periodicals archive ?
The SOD1 A/G polymorphism (rs2070424) is the least studied polymorphism in relation to its association with different diseases.
86 Table 2 Gene expression profile of SOD1, CAT, GR and GPx demonstrated by real time RT-PCR.
Key words: BAC library Bubalus bubalis Murrah breed Pyrosequencing SOD1.
Immunohistochemical analysis revealed that FALS model mice, which express the ALS-linked SOD1 mutant (SOD1(mut)), exhibit activation of ASK1 and p38 concomitant with motor neuron death.
Other theories have been proposed, including defective axonal transport, toxicity of misfolded mutant SOD1 proteins (possibly combined with failure of the proteasome and chaperone systems), contribution from inflammatory responses, and reduced signaling by the vascular endothelial growth factor (Lederer & Santama, 2007).
The only known cause of ALS is mutation of a specific gene: SOD1 gene, according to association's website.
The team tracked the fate of NG2+ cells in both normal mice and mice with a mutant form of the SOD1 gene that causes ALS.
In a study published yesterday in Nature Neuroscience, scientists said the SOD1 gene, which is implicated in 20 percent of inherited cases of ALS, or Lou Gehrig's disease, also plays a part in sporadic forms of the disease.
Approximately 20% of all familial ALS cases are caused by a mutant form of superoxide dismutase, or SOD1.
Why motor neurons in the brain and spinal cord are particularly sensitive to SOD1 mutations is unknown.
A small subset of those with the disease have mutations in the gene for SOD1 that lead to clumping of the protein and the death of neurons that direct motion.
The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice.
She said: "The gene in my family is called SOD1, which is a very appropriate name", she laughs.
A major lead was the identification of several dominant mutations in the superoxide dismutase gene SOD1 responsible for familial-linked ALS, which represents only 10% of all ALS cases (Rosen et al.