Ribosome-inactivating protein and apoptosis: abrin causes cell death via mitochondrial pathway in Jurkat cells.
Ribosome-inactivating proteins are structurally divided into two main groups: type 1 proteins comprise a single A-chain with enzymatic activity, and type 2 proteins comprise an A-chain linked to a lectin B-chain through a disulphide bond, the most well-known type 2 protein being ricin (Stirpe and Battelli 2006).
By damaging rRNA, ribosome-inactivating proteins are capable of activating the ribotoxic stress response with the following induction of mitogen-activated protein kinases (MAPKs) and programmed cell death.
Both caspase-dependent and independent cell death pathways have been described for several ribosome-inactivating proteins (Polito et al.
A comparison of the relative antiviral properties of a number of ribosome-inactivating proteins (RIPs), including PAP, indicated that of all the RIPs tested, none was as effective as PAP.
Endo Y, Tsurugi K, Lambert JM (1988) The site of action of six different ribosome-inactivating proteins form plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins.