Seizures: Mice received pentylenetetrazole
(PTZ; 85 mg [kg.
Effect of pentylenetetrazole
and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues.
Reported protection by aqueous stem bark extract against generalized seizures in pentylenetetrazole
and electro-convulsive models in rodents (Ching et al.
induced changes in zebrafish behavior, neural activity and c-fos expression.
This hypothesis would also explain why flumazenil potentiates the anxiogenic effects of picrotoxin and pentylenetetrazole
(File & Pellow, 1985).
Fernandez found that affected mice were significantly better able to identify novel objects and navigate a maze--tasks that simulate difficulties faced by children and adults with Down syndrome--after being fed 17 daily doses of milk containing a compound called pentylenetetrazole
, or PTZ.
The anticonvulsant activity was screened using maximal electroshock seizure (MES) model and pentylenetetrazole
, isoniazid, gamma aminobutyric acid, glutamate, diazepam (D-907), phenytoin (PHR1139), and vigabatrin were purchased from Sigma Ltd.
Sodium valproate (Sun Pharmaceuticals) and pentylenetetrazole
(PTZ) (HiMedia Laboratories) were used in this study.
Male CD-I mice were kindled with an initial subeffective dose of pentylenetetrazole
Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole
investigated the anticonvulsant effect of carvacrol, (-)-borneol and citral in two animal models of epilepsy, pentylenetetrazole
(PTZ) and maximal electroshock (MES) tests and his results suggest that carvacrol, (-)-borneol and citral possess anticonvulsant activity effect against PTZ-induced convulsions and MES (Quintans-Junior et al.
was purchased from Sigma Chemical (St.
(PTZ)-kindling is a well established animal model which simulates clinical epilepsy.
It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole
in a dose dependent manner and the activity was comparable to phenytoin and diazepam.