Parkinson's disease (PD) is a neurodegenerative disease, where the reduction of dopamine (DA) in the substantia nigra pars compacta
(SNc)-striatal, ventral tegmental area (VTA)-cortex, and VTA-limbic pathways leads to the motor and nonmotor symptoms (NMS) of the disease.
Abbreviations PD: Parkinson's disease DA: Dopaminergic SNpc: Substantia nigra pars compacta
PI3K: Phosphoinositide 3-kinase GSK-3: Glycogen synthase kinase-3 Sal: Salidroside TH: Tyrosine hydroxylase MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPP+: 1-Methyl-4-phenyl-pyridinium Bcl-2: B-cell lymphoma-2 Caspase: Cysteine-dependent aspartate-directed proteases.
Dopamine is produced in the neurons of the pars compacta
region of the substantia nigra within the basal ganglia, but also in other areas of the CNS and throughout the body (Herrero et al.
Tableau 1 Quatre principaux neuromodulateurs ascendants, leurs origines et leurs principales cibles Neuromodulateur Origine de la Cibles principales projection Dopamine (DA) Pars compacta
de la Striatum dorsal substance noire, aire Striatum ventral tegmentale ventrale Cortex frontal Serotonine (5HT) Noyau du raphe dorsal, Cortex, striatum, noyau du raphe median cervelet Hippocampe Noradrenaline (NA) Locus coeruleus Cortex, hippocampe, cervelet Acetylcholine (ACh) Noyau basal de Meynert Cortex, amygdale Septum median Noyau Hippocampe Pars tegmental compacta de la pedonculopontin substance noire, thalamus Colliculus superieur
The neurodegenerative death of dopaminergic neurons in the pars compacta
of the substantia nigra leads to the classic triad of rigidity, resting tremor and bradykinesia (2).
Se presenta en un grupo de celulas nerviosas (neuronas) ubicadas en el area del cerebro conocida como substantia nigra pars compacta
Parkinson's disease is a neurodegenerative disease characterized by the death of dopamine neurons in the substantia nigra pars compacta
of the brain.
The major pathologic feature of PD is the profound loss of pigmented neurons, mainly in the pars compacta
of the substantia nigra (SN).
12) The major feature of Parkinson's disease on MRI appears to be a trend toward a narrowing of the pars compacta
of the substantia nigra.
The flow of neural activity from the two types of putaminal cell, along direct and indirect pathways, appears to be controlled by the nigrostriatal tract, the dopaminergic projection from the substantia nigra pars compacta
(SNc) to the caudate and putamen.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra pars compacta
(SNpc) and an accumulation of ?
Here the main pathological feature is degeneration of neuromelanin-containing neurons in the pars compacta
of the substantia nigra, which leads directly or indirectly to excessive inhibition of the thalamus and consequent bradykinesia.
It is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta
and other parts of the brain, leading to motor impairment, cognitive impairment, and dementia.