The stem cells give rise to all epithelial cells including the enterocytes, goblet cells, Paneth cells
, enteroendocrine cells and Tuft cells.
Wang et al., "Paneth cells
secrete lysozyme via secretory autophagy during bacterial infection of the intestine," Science, vol.
reported a fatal case report of a young woman who developed DRESS from antiepileptic drugs with subsequent HLH diagnosed about 5 months after her initial presentation; with endoscopy biopsies that revealed marked villous atrophy in the duodenum with absence of goblet and Paneth cells
in the duodenum and colon .
Ablation of these cells, but not other niche cells like Paneth cells
, results in severely compromised crypt proliferation.
, goblet cells, absorptive cells, and enteroendocrine cells are the four major secretory cell types in IEC populations , and Paneth cells
play an essential role in controlling bacteria via the secretion of antimicrobial peptides .
: the hub for sensing and regulating intestinal flora.
Reduced Paneth cell
alpha-defensins in ileal Crohn's disease.
(6, 10) Hyperplasia of the foveolar region with irregular glandular branching and epithelial folding is frequently observed with absent goblet and Paneth cells
. (6, 10) On the other hand, the hybrid type harbors morphologic features of both these subsets.
(62) Although NKM 16-2-4 is considered to be an M-cell-specific monoclonal antibody, it also recognizes Paneth cells
but not goblet cells or other epithelial cells.
Goblet cells (in the villus and crypts) and Paneth cells
(in the crypts) were still scarce at 6 days post-challenge in the 5-FU-treated mice regardless of the presence of the APOE gene.
While [alpha]-defensins are produced by polymorphonuclear leukocytes and intestinal paneth cells
, [beta]-defensins are produced by epithelial cells.
As morphogenesis of the intestinal folds proceeds, adult epithelial cells differentiate into major absorptive epithelial cells, goblet cells, and endocrine cells, that is, into all the cell types of mammalian intestinal epithelium except Paneth cells
In the "crypts" of the human gut are immature adult stem cells that live alongside specialized cells called Paneth cells
. The stem cells remain immature as long as they remain in contact with Paneth cells
Specialists in various sciences and medical areas in North America, Europe, Asia, and Saudi Arabia discuss such topics as endoplasmic reticulum stress in the cardiovascular system, the functions of microRNAs in cardiovascular biology and disease, the regulation of insulin secretion in human pancreatic islets, the androgen receptor in health and disease, estrogen and cancer, autophagy and intestinal homeostasis, paneth cells
, the impact of adult neurogenesis on olfactory bulb circuits and computations, the pathophysiology of migraine, the rhythm of breathing, chloride in vesicular trafficking and function, phosphate transporters and their function, and platelets in lung biology.
Intestinal epithelial cell proliferation was reduced in [Lgr4.sup.-/-] mice, with an 80% decrease in crypt Paneth cells
, suggesting that Lgr4 plays a crucial role in intestinal stem cell maintenance ; Lgr4 also appears to play a protective role against inflammatory bowel disease .