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No abnormality was found in cornea on slit lamp biomicroscopy, the only finding on the slit lamp biomicroscopy was pseudoexfoliation in PXS group patients.
The comparison of proportion of ECD 2000 cells/mm2 revealed that PXS cases had significantly higher number of cases 22 (44%) having ECD <2000 as compared to normal healthy subject in which only 2 (4%) subject had ECD <2000 cells/mm2 as given in table-II.
PXS is considered as important cause of secondary open-angle glaucoma called pseudoexfoliation glaucoma (PXG) globally13.
In our study, we studied the endothelial cell density and tried to find out whether there is an impact of PXS on ECD.
In this present study, patients of PXS and control healthy subjects were compared on the basis of quantitative in vivo corneal confocal microscopy findings of the cell density measurements.
Oltulu et al in their study on 57 patients concluded that mean ECD in control (normal) group was 2570 +- 369 cells/mm2 while in patients with PXS was 2124 +- 346 cells/mm2.
Given the aging of the population in Croatia (44), further increase in PXS, PXG and POAG is expected in the future.
Age and gender differences in the prevalence of pseudoexfoliation syndrome (PXS) ([chi squre]-test) PXS NO Yes n % n % 45-49 704 13.60% 1 0.50% Age group 50-59 1363 26.40% 7 3.70% (years) 60-69 1259 24.40% 28 14.90% [greater than or equal to]70 1835 35.60% 152 80.90% Male 1932 38.60% 62 33.00% Gender Female 3075 61.40% 126 67.00% P Age group <0.001 (years) Gender 0.121 Table 6.
No abnormality was found on anterior and posterior segment examination of both eyes on slit lamp biomicroscopy in both groups except for pseudoexfoliation in PXS group patients.
Table-II: Comparison of homocysteine level and homocysteinemia in control and pxs groups.
The main objective of this present study was to find out the association between homocysteine levels with PXS in our study population.
In another study conducted by Puustjarvi T et al, the comparison of plasma HCY levels between patients of PXS and normal controls showed that cases of PXS had significantly raised level of HCY in contrast to normal controls.
Our results are in accordance with the previous studies that put forward the association of hyperhomocysteinemia and PXS. The comparison of proportions of homo-cysteinemia showed that the rate of homo-cysteinemia was significantly greater among patients of PXS in which (96.67%) patients had homocysteinemia as compared with healthy subjects in which (40%) participants had homocysteinemia, who did not have any ocular disease but presented with parallel vascular risk profile18.
Our study showed that eyes of patients with PXS had higher plasma HCY levels as compared to eyes of control subjects.
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