First, we used univariate linear regression to assess the relationships between PKD
clinical characteristics (age of onset, family history, attack duration, type of PKD
, anticonvulsant treatment, and spontaneous remission), mental health symptoms (scores of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism in SCL-90-R), and quality of life (total WHOQoL-100 score).
This mechanism of action has clinical proof of concept to delay the progression of the autosomal dominant form of PKD
When they added back a healthy form of polycystin-1 to our patient cells, it traveled to the cilium and brought its partner polycystin-2 with it, suggesting a possible therapeutic approach for PKD
com/lucy-moore2 For more information about PKD
Gertrude Robert, 80, is the 2011 coordinator of the Worcester Walk for PKD
, founded by the family in 2006 to raise money and awareness.
Meanwhile, several other drugs, including rapamycin, octreotide, and tolvaptan, that succeeded in animal tests for PKD
are now being tested in people.
More information about PKD
can be found online at www.
is the most common human genetic disease, occurring in approximately one in 1,000 births, with an estimated 500,000 Americans suffering from the disease.
can cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain.
causes fluid-filled cysts to form in the kidneys, disrupting their ability to remove harmful toxins from the body.
causes kidneys to fail--which usually happens only after many years--the patient requires dialysis or kidney transplantation.
The majority of familial PKD
was identified to harbor PRRT2 mutations.
Based in Kansas City, the PKD
Foundation is fully committed to discovering treatments and a cure for the disease.
, large cysts form within the kidney and disrupt the organ's function.
In fact, PKD
was reported to be associated with the highest unmet need amongst all renal diseases.