sis

(redirected from PDGFB)
Also found in: Dictionary, Medical, Acronyms.
Graphic Thesaurus  🔍
Display ON
Animation ON
Legend
Synonym
Antonym
Related
  • noun

Synonyms for sis

a female person who has the same parents as another person

References in periodicals archive ?
Higher expression of LAMA4 (p = 0.021), PDGFB (p < 0.001), PDGFRB (p = 0.01), CDH5 (p < 0.001), TJP2 (p = 0.035), and PECAM1 (p = 0.048) was observed in biopaper cocultures compared to PET cocultures.
Four genes, CDH5, TJP2, PDGFB, and VCAM1, with significant roles in BBB maintenance and permeability had significant differences in expression between models across multiple time points (Figure 2).
Secreted by endothelial cells [33], PDGFB plays a critical role in BBB formation and maintenance, acting as a chemoattractant for pericytes [34] and altering gene expression.
PDGFB gene was the second cause of single gene IBGC.[10],[11] The typical clinical characteristics were much milder compared with those carried SLC20A2 mutations, which feature movement disorder and atypical symptoms such as headache slight memory decline and mutations of PDGFB mainly focused on the region of the 2nd exon covering a length of 220-230 bp [Table 3].{Table 3}
As for other genotypes, there were only 2 PDGFRB -positive cases in a screen among Chinese patients of non- SLC20A2 and non- PDGFB .[14] XPR1 -related IBGC has not found in China yet.
Similarly, the mRNA expression levels of transforming growth factor-[beta] (TGF-[beta]), PDGFB, connective tissue growth factor (CTGF), fibronectin 1, and collagen 1A1 increased in the WT mice but decreased in the KO mice upon injection of anti-dsDNA IgG hybridoma cells (Figure 4(c)).
Moreover, the mRNA expression levels of fibrotic markers, such as TGF-[beta], PDGFB, CTGF, fibronectin 1, and collagen 1A1, increase significantly in kidneys of these mice.
The VHL gene encodes a 232-amino-acid protein (pVHL), which is essential in the regulation of the hypoxia-inducible factor (HIF)-1 and HIF-2 affecting the upregulation of vascular endothelial growth factor (VEGF), platelet-derived growth factor beta (PDGFb), transforming growth factor alpha (TGF[alpha]), and erythropoietin substances.
(31) HIF-1[alpha] is a transcription factor that regulates expression of numerous downstream target genes including vascular endothelial growth factor (VEGF), platelet-derived growth factor [beta] (PDGFB), transforming growth factor [alpha] (TGFA), glucose transporter 1 SLC2A1 (GLUT1), and carbonic anhydrase IX (CA9), all of which are important in angiogenesis and for maintaining cellular homeostasis under hypoxic conditions.
Activation of the platelet-derived growth factor receptor [beta] (PDGFRB), a transmembrane tyrosine kinase, by fusion of the gene encoding for its ligand, PDGFB, with COL1A1 (collagen, type 1, a 1) renders dermatofibrosarcoma protuberans responsive to targeted therapy with tyrosine kinase inhibitors, such as imatinib mesylate.
(118,119) Fluorescence in situ hybridization has been used to confirm PDGFB split-apart probes on interphase cells, including paraffin-embedded tissue.
Analysis of the data from the 8 tumor samples showed that amplifications of TP73 (1p36.33), SNRPN (15q12), and PDGFB (22q13.1) occurred exclusively in tumors with a wild type BRAF.
Copy gain of PDGFB occurs in a subset of tumors showing no evidence of mutated BRAF or rearranged ret, suggesting that copy gain of PDGFB may underlie the increased expression of platelet-derived growth factor described recently in the literature.