Tyrosine kinase-like orphan receptors
(Ror) are predominantly located in the plasma membrane (2).
18 September 2014 - US nuclear receptor screening specialist Indigo Biosciences said Thursday it had launched a human estrogen-related orphan receptor
gamma (NR3B3; ERR?
These include statements related to the pending merger between X-Ceptor and Exelixis, the receipt, registration and value of shares, recording of a gain on those shares, and continued development of orphan receptor
technology licensed by Ligand to X-Ceptor subject to future royalty payments.
APOMINE activates the Farnesoid X Receptor (FXR), an orphan receptor
in the nucleus, and a cascade of biological signals within the cells that rapidly induce apoptosis without affecting normal, healthy cells," said Symphar Director of Research and Development Craig Bentzen, Ph.
Other projects are inflammation targeting GR, heart failure/hypertension targeting MR and the orphan receptor
LXR for metabolic disorders.
Karo Bio has also ongoing research programs in the thyroid hormone, glucocorticoid, and orphan receptor
Consequently, it is unclear how these orphan receptors
contribute to bitter taste perception.
Topics include the biology of GPRs, their use as targets in cardiovascular drugs and metabolic disease, the possibilities for them in drug history, their use in molecular bioinformatics, their structures and dynamics, crystallization, novel solid-state NMR methods for structural studies, structural genomics, a molecular basis of dimerization, and orphan receptors
as promising targets.
The agreement allows OSI to access the Cyanamid technology covered in four issued United States patents which include claims for recombinant expression of a variety of targets in yeast, including G-protein coupled receptors, hybrid G-protein coupled receptors and orphan receptors
for use in human therapeutics.
The ligand binding techniques can be used to explore the unprecedented number of new receptor systems now emerging and the orphan receptors
whose activating ligand has not been identified.