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Related to Optic atrophy: glaucoma, optic neuritis
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References in periodicals archive ?
Genetic testing for autosomal dominant optic atrophy (OPA1) and spinocerebellar ataxia 1-8 and 17 were negative.
* The report provides a snapshot of the global therapeutic landscape of Leber's Hereditary Optic Neuropathy (LHON) (Leber optic atrophy)
In a small, pilot open-label trial, seven patients with confirmed dominant optic atrophy (DOA) were treated with idebenone (270-1000 mg/day) for at least one year and the authors reported improved visual function in all patients when compared to baseline [55].
Colour vision was severely impaired (0/15 on Ishihara pseudoisochromatic plates) and funduscopy revealed bilateral profound optic atrophy (Fig.
Recently, mutations in OPA1 and MFN2 have been described in patients with autosomal dominant optic atrophy (ADOA) and multisystem clinical involvement (including progressive external ophthalmoplegia (PEO)) who harbored mitochondrial DNA (mtDNA) deletions in skeletal muscle [16-18](Table 1, Figure 1(a)).
Common congenital abnormalities of the eyes were, cataract in 116(22.6%) cases, lacrimal apparatus anomalies in 103(20%), ptosis in 45(8.8%), pigmentary retinal degeneration in 35(6.8%), microopthalmos/ anopthalmos in 26(5%), optic atrophy in 23(4.5%) followed by other abnormalities (Table-2).
The disease is also known as DIDMOAD, short for Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness, the names of all the disorders it causes.
Infantile malignant osteopetrosis (arOP; ARO; OMIM 259700) is an autosomal recessive disease manifesting with anaemia, thrombocytopenia, hepatosplenomegaly, visual impairment due to optic atrophy and deafness.
In the literature we find a wide spectrum of ocular manifestations, which includes: corneal edema, corneal infiltration, chemosis, ciliary injection, mucopurulent keratoconjunctivitis, anterior uveitis, hyphema, iris atrophy, cataract, lens subluxation, anterior and posterior capsule opacities, trabeculitis, damage of the trabecular mesh and glaucoma, ophthalmoplegia, optic neuritis, papilledema and optic atrophy (3,4).
The major causes of blindness in Aboriginal adults were revealed as cataracts (32 per cent), followed by refractive error (14 per cent), optic atrophy (14 per cent), trachoma (nine per cent) and diabetic eye disease (nine per cent).
Smith, 27, lost her eyesight eight years ago, she says, "through a series of eye diseases--keratoconus, optic atrophy and, finally, a brain tumor I was diagnosed with about three years ago.
There are a number of signs that are atypical of optic neuritis and their presence should alert ophthalmologists to diagnose other than inflammatory demyelination, such as optic atrophy on presentation, severe disk oedema with vitreous reaction, optic disk hemorrhage, painless loss of vision, and lack of signs of recovery within 3 weeks of onset of symptoms (107).
This may lead to facial nerve palsy causing hearing loss, visual problems, neurological pain and, very rarely, blindness as a consequence of optic atrophy. Bone anomalies appear in the first decade of life and become more prominent among the elderly.
He has a genetic condition called optic atrophy which is causing him to lose his sight, and Thomas is also showing problems with his eyes.
Fifteen-year-old Chris, of Brighouse, suffers from Leber's optic atrophy, an eye condition which gradually causes blindness.