Commercial opportunity remains for opioid analgesics
with lower risk of abuse and/or dependence.
, epidural blocks, and alternative therapies are all options to be considered in the therapeutic treatment of pain for laboring patients.
Due to these concerns from regulatory authorities and physicians about growing opioid abuse, there has been a seismic shift towards developing abuse-resistant formulations of extended-release opioid analgesics
, including both novel products and reformulations of existing ones.
Because opioid analgesics
are widely used among women of reproductive age for pain, any potential detrimental effects of these drugs during pregnancy clearly are important to a large population of women.
From 1999 to 2006, the number of hospitalizations for poisonings related to opioid analgesic
, sedative, and tranquilizer use increased 65% while unintentional poisonings by these three drug categories increased 37% (Coben et al.
4 Require patients to sign a pain management agreement (contract) for all patients receiving prescriptions for Schedule II or Schedule III opioid analgesics
(a sample is available from the author on request).
2 per 1,000 total claims) were for an oral opioid analgesic
Incorporating opioid analgesics
in the treatment of chronic nonmalignant pain is effective in the appropriate patient population.
Data from the trial will be used to help estimate the serious risk for the development of hyperalgesia following use of extended-release long-acting (ER/LA) opioid analgesics
to treat chronic pain for at least one year.
Tramadol, a centrally acting synthetic opioid analgesic
approved for the management of moderate to moderately severe chronic pain, is marketed as Ultram and Ultracet (tramadol with acetaminophen) by PriCara, a division of Ortho-McNeil-Janssen Pharmaceuticals.
In contrast, European physicians are more likely to prescribe the dual-acting opioid analgesic
tramadol (multiple brands, generics) to a greater percentage of their acute pain patients than physicians in the U.
These companies are known as REMS Program Companies (RPC), representing a consortium of approved drug application holders of branded and generic ER/LA opioid analgesic
drug products that was formed for the specific purpose of implementing this REMS.
Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for NUCYNTA ER (tapentadol) extended-release tablets, an oral analgesic taken twice daily, for the management of neuropathic pain associated with diabetic peripheral neuropathy (DPN) in adults when a continuous, around-the-clock opioid analgesic
is needed for an extended period of time.
com) announces updates to their Opioid Analgesic
BEMA Buprenorphine utilizes BDSI's proprietary BioErodible MucoAdhesive (BEMA) drug delivery technology, which consists of a small, dissolvable, polymer film for application to the buccal mucosa (inner lining of the cheek) to deliver the opioid analgesic