As we have seen earlier, large numbers of patients are not consuming opioid analgesics
as prescribed and several thousands are using them without prescription.
Among the changes, the FDA is requiring boxed warnings (the FDA's strongest warning) and patient-focused Medication Guides for prescription opioid analgesics
, opioid-containing cough products and benzodiazepines--nearly 400 products in total--with information about the serious risks associated with using these medications at the same time.
In exploratory analysis, gastroschisis also was significantly associated with opioid analgesic
exposure in early pregnancy (OR, 1.
From a clinical perspective, given the proportion of unplanned pregnancies and the high prevalence of opioid analgesic
dispensing in the United States, the potential for pregnancy should be considered when these medications are prescribed for women in their reproductive years.
, epidural blocks, and alternative therapies are all options to be considered in the therapeutic treatment of pain for laboring patients.
Due to these concerns from regulatory authorities and physicians about growing opioid abuse, there has been a seismic shift towards developing abuse-resistant formulations of extended-release opioid analgesics
, including both novel products and reformulations of existing ones.
had the greatest increase in impact on health care resources during the study period--ED visits increased by 101%, injury rates increased by 92%, and hospital admission rates increased by 86%.
Nearly a third (33%) of opioid analgesic
overdose deaths involved no other drugs; 17% involved benzodiazepines, 15% involved heroin or cocaine, and 3% involved benzodiazepines in combination with heroin or cocaine.
Then in a December 2008 JAMA article, researchers reported on the "pharmacoepidemic" in West Virginia: the majority of overdose deaths in West Virginia in 2006 were associated with the diversion of pharmaceuticals, primarily opioid analgesics
Subjects with at least one claim for any opioid analgesic
or for controlled-release oxycodone were older, were slightly more likely to be female, and had higher mean chronic disease scores than the overall study population.
It will connect healthcare providers to information and resources aimed at supporting the safe and effective management of their patients with chronic pain who are appropriate for treatment with an opioid analgesic
The bill, titled Health Insurance Coverage for Opioids, would allow health insurance policies that already cover opioid analgesic
drag products to preauthorize brand name versions of the medications.
This report describes a 29% decline in the opioid analgesic
-involved overdose death rate in Staten Island from 2011 to 2013, while the rate did not change in the other four NYC boroughs, and compares opioid analgesic
prescribing data for Staten Island with data for the other boroughs.
Treatment with an opioid analgesic
between 1 month before and 3 months after conceiving was associated with a significantly increased risk of the following malformations in their infants: conoventricular septal defects (odds ratio, 2.
The present trend of increasing medical use of opioid analgesics
to treat pain does not appear to be contributing to increases in the health consequences of opioid analgesic