The past 15 years have seen great advances in the investigation of nucleic acids
and their components, with progress being made in the areas of accurate mass determination, sequencing, study of noncovalent interactions, characterization of isolated and synthetic DNA and RNA, and more.
a Netherlands holding company with subsidiaries in Germany, the United States, Japan, the United Kingdom, Switzerland, France, Italy, Australia, Norway, Austria, Canada, and the Netherlands believes it is the world's leading provider of innovative enabling technologies and products for the separation, purification and handling of nucleic acids
Synthetic nucleic acids
is a fast growing segment of nucleic acid
research and genomics used for the analysis of nucleic acid
In the early 1990s, scientists created this DNA mimic by combining nucleic acids
with a protein backbone.
This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids
, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.
With manufacturing facilities in both North America and Europe, Proligo is ideally positioned to supply the global nucleic acids
Pointing out the versatility of coenzymes, Ferris adds that "they may have survived because they can do some tasks that neither nucleic acids
nor proteins can do.
Assembling contributions from a collection of authors with expertise in all areas of nucleic acids
, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids
presents a thorough overview of nucleic acid
chemistry - a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs.
proteins, antibodies having selectivity for such proteins, inhibitors of such proteins and/or nucleic acid
molecules, cells transformed with said nucleic acid
molecules, assays employing such cells, nucleic acids
molecules, proteins, antibodies and/or inhibitors, and therapeutic compositions comprising said nucleic acids
molecules, proteins, antibodies and/or inhibitors.
are essential components of the genetic material of all organisms and are proving increasingly important in opening up new dimensions in diagnostic and therapeutic applications.
In essence, these scientists highlight the fact that life based on replicating nucleic acids
such as RNA and DNA is only one example -- albeit a powerful one -- of a general chemical phenomenon.
Therapeutic nucleic acid
drugs are short fragments of nucleic acids
with defined chemical structure (sequence).
The invention also features nucleic acids
encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids
encoding the antibodies or antibody fragments, vectors comprising the nucleic acids
, and cells comprising the vectors.
These protocells led to the subsequent evolution of nucleic acids
and ultimately gave rise to self-sustaining cellular life.
It focuses on the methods for obtaining modified and native nucleic acids
, and their biological applications.