reverse transcriptase inhibitor

(redirected from Non-nucleoside reverse transcriptase inhibitors)
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Related to Non-nucleoside reverse transcriptase inhibitors: Protease inhibitors, Entry inhibitors, fusion inhibitors, Integrase inhibitors
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  • noun

Words related to reverse transcriptase inhibitor

an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV

References in periodicals archive ?
This effect was not seen in patients who were not exposed to protease inhibitors and was not associated with exposure to non-nucleoside reverse transcriptase inhibitors, although patients were not exposed to this class of drug for as long.
Tibotec also presented the first clinical results of a new non-nucleoside reverse transcriptase inhibitor (NNRTI), TMC278; and data on a novel class of nucleotide-competitive reverse transcriptase inhibitors (NcRTIs).
ATRIPLA contains 600 mg of efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate, both nucleoside reverse transcriptase inhibitors (NRTIs).
In the United States and the European Union, Truvada is indicated in combination with other antiretroviral agents (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors) for the treatment of HIV-1 infection in adults.
Even in the industrialized world, where highly active antiretroviral therapy or HAART (comprising combinations of nucleoside and non-nucleoside reverse transcriptase inhibitors and protease inhibitors) has transformed the outlook for AIDS sufferers, the problems of drug resistance, cumulative toxicity and poor patient compliance have tempered initial optimism that AIDS might evolve into a chronic, treatable condition.
As an example of the impact of PIs, before PIs the outlook for non-nucleoside reverse transcriptase inhibitors (NNRTIs) was dim.
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) can cause elevated liver enzymes, a sign of liver stress and potential damage.
The indication for FUZEON in the European Union is for "use in combination with other antiretroviral medicinal products for the treatment of HIV-1 infected patients who have received treatment with and failed on regimens containing at least one medicinal product from each of the following antiretroviral classes, protease inhibitors, non-nucleoside reverse transcriptase inhibitors and nucleoside reverse transcriptase inhibitors, or who have intolerance to previous antiretroviral regimens.
Patients in the PRT arm received significantly more active drugs and fewer non-nucleoside reverse transcriptase inhibitors (NNRTIs).
1) Previously treated with three classes of antiretrovirals: nucleoside analogues, non-nucleoside reverse transcriptase inhibitors and protease inhibitors.
Of note, these volunteers were naive to non-nucleoside reverse transcriptase inhibitors (NNRTIs), and the contribution of efavirenz (Sustiva) to the virologic success of their treatment should not be underestimated.
References: (1) Previously treated with three classes of antiretrovirals: nucleoside analogues, non-nucleoside reverse transcriptase inhibitors and protease inhibitors.
The study is being conducted in patients who are experienced with multiple protease inhibitors but who have not been treated with non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Existing categories -- nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs) -- as well as novel categories such as entry inhibitors, immune-based therapies, zinc finger inhibitors and integrate inhibitors have several drugs in the pipeline that can address the urgent requirement for new antiretroviral drugs," says Frost & Sullivan Research Analyst Raghunath Tantry.
Capravirine, which demonstrates a novel HIV resistance profile in preclinical studies, is a member of the class of agents known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
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