To our knowledge there are no reports in the literature where a patient developed NMS after bilateral hip arthroplasty, nor has a case been published in which NMS developed in a patient taking longterm neuroleptics
, with no acute omission, introduction, or change in dose.
malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic
malignant syndrome (NMS) is an uncommon but potentially fatal idiosyncratic reaction to neuroleptics
, characterized by a distinctive clinical syndrome of mental status change, rigidity, fever, and dysautonomia (1).
Malignant Syndrome (NMS) is an idiosyncratic and potentially life-threatening reaction to neuroleptic
7] Also dopamine agonist bromocriptine, the GABA agonist baclofen, calcium channel blockers and clonazepam might be successful in treatment of this disabling complication of treatment with neuroleptics
19) Olmsted has suggested the following guidelines for administration of neuroleptics
after NMS resolution.
However, more research is needed towards better understanding the role of somatic factors that might trigger the psychoses and the efficacy (acute phase and prophylaxis) of neuroleptics
agents, benzodiazepines, anticonvulsive agents and electroconvulsive therapy (3).
More recently, researchers established a positive association between higher scores on the Liverpool University Neuroleptic
Side Effects Rating Scale and D2/D3 receptor occupancy in the ventral striatum (nucleus accumbens and olfactory tubercle).
malignant syndrome is considered as a rare but potentially fatal complication of neuroleptic
Adults seem to improve with antidepressants and neuroleptics
, but children and teens do not reap the same benefit, Dr.
While adults with the disorder seem to improve with some antidepressants and neuroleptics
, children and teens do not reap nearly the same benefit, Dr.
Detection of existing mammary tumor by breast examination or studies (mammogram) is recommended prior to administration of neuroleptics
malignant syndrome: A complication of neuroleptics
and cocaine abuse.
class of drugs called atypical neuroleptics
has become commonly prescribed for schizophrenia, in part because they seem to improve problems like delusions, hallucinations and dementia linked with the neurodegenerative disease.
A meta-analysis updated and expanded 22 previously published studies conducted between 1996 and 2007, involving falls among 79 081 participants aged over 60, and evaluated nine drug classes--antihypertensive agents, diuretics, beta-blockers, sedatives and hypnotics, neuroleptics
and antipsychotics, antidepressants, benzodiazepines, narcotics, and non-steroidal anti-inflammatory drugs.