However, there are few reports on the effect of traditional Chinese medicines, such as icariin, on NP and annulus fibrosus cells, although, as an old Chinese traditional medicine, icariin has been reported to benefit osteogenesis in vivo , accelerate the differentiation of osteoblast and mesenchymal stem cells , and protect neurocytes
Georgakilas et al., "Tetramethylpyrazine (TMP) protects cerebral neurocytes
and inhibits glioma by down regulating chemokine receptor CXCR4 expression," Cancer Letters, vol.
To date, DPSCs had been successfully induced into odontoblasts, osteoblasts, chondrocytes, myocytes, neurocytes
, adipocytes, corneal epithelial cells, melanoma cells and induced pluripotent stems.
Histological observations showed that the pESCs were able to form teratomas containing the three germ layers of gastrointestinal tissue (endoderm), cartilage (mesoderm), and neurocytes
(ectoderm) (Figure 1(d)).
Some authors reported that CNS ischemic injuries enhance membrane destructive processes in neurocytes
and glial cells resulting in release of their specific components into circulation.
Although it is known from animal experiments that nicotine changes the development of the brain and leads to a damaging of neurocytes
, it cannot be ruled out that the reduced thickness of the frontal cortex region found in the case of the participants in the study already existed before they started smoking.