reduce sodium excretion by the kidneys, which raises blood pressure.
When a patient requires an NSAID
for muscle or joint pain associated with arthritis, finding an effective NSAID
can be a matter of trial and error.
"American College of Gastroenterology guidelines for management of IBD recognise NSAIDs
as potential triggers for disease exacerbation, highlighting the ongoing concern regarding the use of these medications in patients with established disease," wrote Oluwatoba Moninuola, MBBS, of Harvard University T.H.
SAFETY: Regarding NSAID
safety, the Arthritis, Rheumatism, and Aging Medical Information System estimates that adverse effects due to NSAIDs
are associated with more than 100,000 hospitalizations and more than 16,000 deaths in the U.S.
After multivariable analysis, first author Oscar Viteri, MD, and his colleagues reported that 70% of patients who received NSAIDs
had persistent postpartum hypertension, defined as a blood pressure of at least 150 mm Hg or a diastolic BP of at least 100 mm Hg obtained on two occasions at least 4 hours apart.
They found that taking any dose of NSAIDs
, including ibuprofen and naproxen, for a week, a month or more than a month was associated with a greater heart attack risk.
The primary endpoint was differences in gastrointestinal symptom scores and health-related QOL scores between users and nonusers of NSAIDs
and LDA at peptic ulcer onset, compared with the following patient groups: NSAID-only, LDA-only, NSAIDs
+ LDA, and nonusing (neither NSAIDs
The Proprietary Association of Great Britain, the trade association representing manufacturers of branded over-the-counter medicines, stressed the patients were given NSAIDs
The study by a team from Milano-Bicocca University in Italy showed increased risk in seven traditional NSAIDs
. These are diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide and piroxicam.
Each year, more than 15 per cent of the population in western countries are given a prescription for NSAIDs
. This figure increases with age.
Jones notes that the bleeding risk is especially high for patients taking NSAIDs
in combination with other blood-thinning agents; these include aspirin, warfarin (Coumadin), the newer anticoagulants used to treat atrial fibrillation (Pradaxa, Xarelto, Eliquis), and antiplatelet agents that are given after having a stent placed (Plavix, Effient).
After examining the data of over 30,000 patients with high blood pressure, researchers at the Institute of Population Health Sciences, National Health Research Institutes in Zhunan, Taiwan, found that those who'd been taking NSAIDs
for at least three months were 32% more likely to have chronic kidney disease than those who didn't take NSAIDs
Since discovery of an increased risk of cardiovascular (CV) events with nonsteroidal anti-inflammatory drugs (NSAIDs
) a decade ago, additional analyses have been conducted to provide further insight and assess if differences exist among the NSAIDs
regarding CV risk.
Another day, another achy joint, another dose of nonsteroidal anti-inflammatory drugs (NSAIDs
Non-steroidal anti-inflammatory drugs (NSAIDs
) comprise a group of medicines that exert their action by inhibiting cyclooxygenase (COX) isozymes.