Evans and Baird compared the NOAEL
estimates for 35 pesticides derived from censored and uncensored datasets .
Calabrese's team reviewed hundreds of toxicology papers that document a biological effect below the NOAEL
for chemical poisons.
For example, the estimation of the NOAEL
is sufficient information for a decisionmaker who seeks to reduce the exposure of the maximally exposed individual to a level equaling the NOAEL
divided by some safety factor.
Taken together, the observation of higher mammary adenocarcinoma incidence and DLP ductal adenocarcinoma multiplicity identified solely with perinatal exposure to 25 [micro]g BPA/kg-BW indicates that maximal carcinogenic BPA responses may uniquely occur with developmental-specific exposure at BPA doses well below those typically studied and far below the current NOAEL
. This finding is consistent with earlier predictions by Soto and colleagues (Munoz-de-Toro et al.
Values of [LD.sub.50] over 2000 mg/kg and NOAEL
between 200 and 1000 mg/kg body weight/day have been reported for lutein.
Stezenie 0,1 mg/[m.sup.3] zostalo okreslone jako NOAEL
. Pauluhn  sugeruje, ze efekt toksyczny dzialania nanorurek weglowych wynika z efektu przeladowania pluc CNT.
The MTD and NOAEL
dose levels of [beta]-eudesmol were 100 mg/kg body weight.
For derivation of the ADE value, the objective is to define the no-observed-adverse-effect level (NOAEL
) for the clinically significant critical effect.
For many substances, it is possible to establish a level at which toxicological reactions no longer appear if the exposure level is sufficiently low, i.e., such substances show no-observed-adverse-effect level (NOAEL
The reported no-observed-adverse-effect level (NOAEL
) for fresh-pressed E.
The oral no-observed adverse effect value (NOAEL
) of steroidal saponins from D.
And it's not that proper information was lacking; studies already published at the time had reported a no observable adverse effect level (NOAEL
) - that is, not a toxic but a safe level - ranging between 40 and 280 [micro]g/kg.
The No-Observed-Adverse-Effect-Level (NOAEL
) was found to be 700 ppm for male rats and 300 ppm for females.
Based on the results of the repeated dose 90-day oral toxicity, the no observed adverse effect level (NOAEL
) of PartySmart was 1000 mg/kg b.wt.
Developmental toxicity NOAEL
and postnatal recovery in rats fed boricacid during gestation.