in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with usual ductal hyperplasia.
Recent studies have shown that EPC lacks myoepithelial cells
both within and outside of the lesion, thus proving it to be a separate entity.
Expression of class II beta tubulin by proliferative myoepithelial cells
in canine mammary mixed tumors.
Clumping of intercellular stromal and myxoid matrix material and myoepithelial cells
show fuzzy borders, fragile cytoplasmic processes and nucleoli.
The myoepithelial cells
were located at the base of the acinar cell and were stellate shaped.
The tumor was composed of neoplastic myoepithelial cells
arranged in a fascicular nested pattern separated by collagen stroma (Figure 1).
It was also strongly stained around the myoepithelial cells
surrounding sebaceous and stromal cells.
The former may be part of a continuum with mixed tumors (ductal structures but few myoepithelial cells
The tubules are lined by cuboidal or low columnar cells with round uniform nuclei resting on a myoepithelial cell
The morphologic spectrum of myoepithelioma has been expanded with the recent application of diverse cellular and ultrastructural modifications of myoepithelial cells
. (16) Several investigators have included in this spectrum a few tumors with glandular differentiation; tumors in which the ducts comprise no more than 5 to 10% of the sections are classified as myoepitheliomas.
The cytologic features of apocrine cells can be worrisome and, if associated with a reduction or loss in the myoepithelial cell
layer, may prompt an erroneous diagnosis of malignancy.
Pleomorphic adenoma of soft palate: Myoepithelial cell
Under low-power examination, a prominent myoepithelial cell
(MEC) layer can be seen at the periphery of the ducts.
Most breast cancers and other breast tumors have an epithelial cell origin, with stromal and myoepithelial cell
tumors being less common.
A benign intraductal papillary lesion is characterized by the presence of a layer of intervening myoepithelial cells
in the fibrovascular fronds, whereas its malignant counterpart lacks an intact myoepithelial cell
layer within the papillae.