2008) Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins
19) In another study, mice were induced with EAE and treated with progesterone had a decreased clinical severity and enhanced expression of transcription factors essential for oligodendrocyte and myelin protein
Several groups worldwide are developing vaccines using pieces of myelin proteins
, or peptides--which are targets for immune T cells--to induce immunity to the MS attack by these cells.
In vivo detection of myelin proteins
in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology.
Additionally, the immunology data shows that reactivity to all three of the key myelin proteins
(MOG, PLP and MBP) was broadly present in study patients, which may be an important finding for the future treatment of MS.
Stephen Miller, PhD, and his team at Northwestern University Feinberg School of Medicine in Chicago, have shown that mice with an MS-like disease called EAE have fewer relapses when they are treated with a mixture of small bits of myelin proteins
and signal cells programmed to suspend T cell activation.
Annotations in the Ciona model, the presence of conserved protein domains (Marchler-Bauer and Bryant, 2004), and relatedness to subject myelin proteins
in the reciprocal BLASTP searches were used as the basis for accepting or rejecting model sequences as being myelin protein
EGR2 is a zinc-finger transcription factor that regulates the expression of myelin proteins
Repeatedly injecting mice with myelin proteins
stimulated their immune systems to mount an attack on these molecules.
Other researchers have partially healed spinal cord injuries in animals by blocking the inhibitory myelin proteins
or engrafting peripheral nerve cells into the damaged areas (SN: 7/27/96, p.
To follow up on their study, they induced an MSlike disease in mice by injecting a combination of myelin proteins
Many different brain proteins, including myelin proteins
as well as astrocytic or neuronal proteins, can induce a T-cell response, which gives rise to inflammation in the brain or spinal cord.
Under normal conditions, some T-lymphocytes "react" specifically to the body's myelin proteins
In MS, the immune response appears to be against more than one of the myelin proteins
Using a computer to compare the various sequences, they found similarities between sections of measles, Epstein-Bar, influenza A and B, and upper respiratory tract viruses and two myelin proteins
that had previously been found capable of inducing neurological disease in laboratory animals.