CARDIOVASCULAR DRUGS THAT MAY REACT WITH GRAPEFRUIT RISK DRUG POTENTIAL COMPLICATION VERY HIGH dronedarone (Multaq) torsades de pointes lovastatin (Mevacor
) rhabdomyolysis simvastatin (Zocor) rhabdomyolysis HIGH amiodarone torsades de pointes (Cordarone) atorvastatin rhabdomyolysis (Lipitor) clopidogrel (Plavix) loss of efficacy * eplerenone (Inspra) high blood calcium levels, serious arrhythmias ticagrelor gastrointestinal or (Brilinta) kidney bleeding INTERMEDIATE felodipine (Plendil) low blood pressure, peripheral edema nifedipine low blood pressure, (Procardia) peripheral edema quinidine torsades de pointes (Quinidine) rivaroxaban gastrointestinal (Xarelto) bleeding * In 2010, it was reported that grapefruit renders certain drugs less effective or ineffective.
Similarly, lab tests have shown that Zocor and Mevacor
readily kill ovarian, uterine and cervical cancer cells in lab dishes, but lipophobic Pravachol does not.
A study by the University of Massachusetts Medical School published online Monday in the Archives of Internal Medicine, a publication of the Journal of the American Medical Association, found that women older than 50 who use statin drugs such as Lipitor, Zocor, Pravachol, Crestor and Mevacor
to reduce cholesterol are at a significantly higher risk of developing type 2 diabetes.
Medications studied were atorvastatin (Lipitor), lovastatin (Mevacor
), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor).
Red yeast rice naturally contains the cholesterol-lowering statin compound lovastatin, the active ingredient in prescription Mevacor
. Labels on red yeast rice products, however, generally do not disclose lovastatin content due to concern that the supplement will be considered an unapproved drug by the FDA and removed from the market.
Drugs affected by the revisions include: Cozaar, Crixivan, Hyzaar, Isentress, Janumet, Januvia, Mevacor
, Noroxin, Prinivil, Prinizide, Propecia, Proscar, Singulair, Zocor, and Zolinza.
Examples of statin drugs include lovastatin (Mevacor
), simvastatin (Zocor).
The original statin, Merck's Mevacor
, came on the market in 1987.
(New York), to 63 for people taking Merck & Co.'s (Whitehouse Station NJ) Mevacor
, or lovastatin.
Researchers overstimulated brain cells in animals, then treated the cells with the statin drug lovastatin (Altoprev, Mevacor
The first statin was Mevacor
, manufactured by Merck and officially approved for cholesterol lowering in individuals with the rare condition of Familial Hypercholesterolemia (FH) in 1987.
Merck filed for approval for OTC use of a fixed daily 20-mg dose of lovastatin, marketed as Mevacor
, "to help lower cholesterol, which may prevent a first heart attack," focusing on a moderate-risk population.
has sought permission to sell lovastatin (Mevacor
) over the counter in the United States.
market: Lipitor (atorvastatin), Lescol (fluvastatin), Mevacor
(lovastatin), Pravachol (pravastatin), and Zocor (simvastatin).
The overall birth prevalence of any isolated lower-limb defect or VACTERL anomaly is estimated as 1:100,000 and ranges from 1:50,000 for simvastatin (Zocor) to 1:500,000 for lovastatin (Mevacor