The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine
Sodium thiosulfate is used in the treatment of mechlorethamine
(nitrogen mustard) burns (Dorr, 1990; Oncology Nursing Society, 1992).
Pronunciation: Me-klor-ETH-a-meen Commonly referred to as: Nitrogen Mustard Brand names: A commonly used brand name is Mustargen[R].
Valchlor gel has been formulated as a once-daily, topical application that dries on the skin, and it is the only FDA-approved formulation of mechlorethamine
Chemotherapeutic regimens currently recommended for Hodgkin lymphoma are: ABVD- doxorubicin (Adriamycin), bleomycin, vinblastine, dacarbazine; Stanford V mechlorethamine
, vincristine, prednisone, doxorubicin, bleomycin, vinblastine, etoposide; and COPP- cyclophosphamide, Oncovin, procarbazine, prednisone.
If it gets clearance, VALCHLOR would be the first and only FDA-approved topical formulation of mechlorethamine
for the treatment of early-stage mycosis fungoides-type cutaneous T-cell lymphoma, the pair notes.
Richard Schilsky, on the 60th anniversary of the approval of mechlorethamine
Sodium thiosulfate is the only antidote currently recommended by ONS for extravasation of mechlorethamine
or concentrated cisplatin.
MOPP - mechlorethamine
+ oncovin (vincristine) + procarbazine + prednisone
The drug is known in the USA as mechlorethamine
gel and is currently undergoing review by the US drug regulator for early stage (stages I-IIA) mycosis fungoides, a type of CTCL.
Until 1946, government secrecy restrictions prevented publication of small case series, but the experiments continued, and on March 15, 1949, mechlorethamine
(Mustargen) became the first chemical agent to receive Food and Drug Administration approval for the treatment of cancer, transforming an agent of death into one that held the promise of extended life and launching a revolution.
M2 PHARMA-October 4, 2011-FDA accepts for filing Yaupon's mechlorethamine
gel NDA(C)2011 M2 COMMUNICATIONS